Squeezing hydrogels for controlled oral drug delivery

被引:133
作者
Gutowska, A
Bark, JS
Kwon, IC
Bae, YH
Cha, Y
Kim, SW
机构
[1] UNIV UTAH,DEPT PHARMACEUT & PHARMACEUT CHEM,CTR CONTROLLED CHEM DELIVERY,SALT LAKE CITY,UT 84112
[2] MACROMED INC,SALT LAKE CITY,UT 84108
关键词
controlled oral drug delivery; temperature-sensitive hydrogels; pH-sensitive hydrogels; swelling/deswelling kinetics; drug delivery device;
D O I
10.1016/S0168-3659(97)00041-2
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A new delivery device based on a novel, squeezing hydrogel concept, utilizing specific swelling-deswelling characteristics of temperature-, temperature/pH- and pH-sensitive hydrogels is described. These hydrogels have been designed to exhibit controlled swelling-deswelling kinetics, hence, a variety of release profiles may be generated including: delayed, zero-order or on-off release profiles. A temperature sensitive NiPAAm/AAc hydrogel demonstrated a squeezing controlled 'on-off' release profile in response to a temperature change between 35 degrees and 40 degrees C with the 'on' phase at higher temperature. Drug release profiles from a pH/T sensitive NiPAAm/BMA/DEAEMA hydrogel were strongly affected by a pH change at 37 degrees C. The gel demonstrated a minimal delayed release at pH 2.0 and a zero-order release at pH 7.4 controlled by mechanical squeezing mechanism that was determined by the gel deswelling kinetics. A delayed and a zero-order release profiles were also obtained for a pH sensitive cationic hydrogel in response to a pH change from pH 2.0 to 7.4. For all studied systems, it was concluded that a gel composition and an applied stimuli (T, pH, pH/T), determined the gel swelling/deswelling kinetics and the release profiles. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:141 / 148
页数:8
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