From morphogen to morphogenesis and back

被引：224

作者：

Gilmour, Darren ^{[1
]}

Rembold, Martina ^{[2
,3
]}

Leptin, Maria ^{[1
,2
]}

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

[2] Univ Cologne, Inst Genet, D-50674 Cologne, Germany

[3] European Mol Biol Org, D-69117 Heidelberg, Germany

来源：

NATURE | 2017年 / 541卷 / 7637期

关键词：

CELL-SHAPE CHANGES; NEURAL-TUBE CLOSURE; APICAL CONSTRICTION; ADHERENS JUNCTIONS; DROSOPHILA GASTRULATION; CONVERGENT EXTENSION; TISSUE MORPHOGENESIS; EPITHELIAL MORPHOGENESIS; MYOSIN-II; PLANAR POLARITY;

D O I：

10.1038/nature21348

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

A long-term aim of the life sciences is to understand how organismal shape is encoded by the genome. An important challenge is to identify mechanistic links between the genes that control cell-fate decisions and the cellular machines that generate shape, therefore closing the gap between genotype and phenotype. The logic and mechanisms that integrate these different levels of shape control are beginning to be described, and recently discovered mechanisms of cross-talk and feedback are beginning to explain the remarkable robustness of organ assembly. The 'full-circle' understanding of morphogenesis that is emerging, besides solving a key puzzle in biology, provides a mechanistic framework for future approaches to tissue engineering.

引用

页码：311 / 320

页数：10

共 144 条

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Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium of Drosophila [J].