Syntheses and antiviral activities of 1,3-dioxolanyl-, 1,3-oxathiolanyl- and 1,3-dithiolanylnucleosides with 2-hydroxymethyl substituents

被引：10

作者：

Chun, MW

Shin, DH

Moon, HR

Lee, JW

Park, H

Jeong, LS

机构：

[1] KOREA ADV INST SCI & TECHNOL,DIV APPL SCI,SEOUL 136650,SOUTH KOREA

[2] EWHA WOMANS UNIV,MED CHEM LAB,COLL PHARM,SEOUL 120750,SOUTH KOREA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(97)00250-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel 1,3-dioxolanyl-, 1,3-oxathiolanyl- and 1,3-dithiolanylnucleosides with 2-hydroxymethyl substituents (1a-4b) were each synthesized with good yields through the condensation of dinucleophiles (oxygen and/or sulfur) with 1,3-dibenzoxy-2-propanone methyl ketal as a key step. (C) 1997 Elsevier Science Ltd.

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页码：1475 / 1480

页数：6

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