The biosynthesis and regulation of bacterial prodiginines

被引:388
作者
Williamson, Neil R.
Fineran, Peter C.
Leeper, Finian J.
Salmond, George P. C.
机构
[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England
[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
基金
英国生物技术与生命科学研究理事会;
关键词
D O I
10.1038/nrmicro1531
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The red-pigmented prodiginines are bioactive secondary metabolites produced by both Gram-negative and Gram-positive bacteria. Recently, these tripyrrole molecules have received renewed attention owing to reported immunosuppressive and anticancer properties. The enzymes involved in the biosynthetic pathways for the production of two of these molecules, prodigiosin and undecylprodigiosin, are now known. However, the biochemistry of some of the reactions is still poorly understood. The physiology and regulation of prodiginine production in Serratia and Streptomyces are now well understood, although the biological role of these pigments in the producer organisms remains unclear. However, research into the biology of pigment production will stimulate interest in the bioengineering of strains to synthesize useful prodiginine derivatives.
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收藏
页码:887 / 899
页数:13
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