Stem cells from umbilical cord blood

被引:23
作者
Sanchez-Ramos, Juan [1 ]
机构
[1] Univ S Florida, Dept Neurol MDC 55, Tampa, FL 33612 USA
关键词
stem cells; umbilical cord blood; plasticity; central nervous system;
D O I
10.1055/s-2006-952150
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The study of hematopolesis, the generation of blood cell lines throughout life, has provided conceptual, experimental, and therapeutic approaches useful to an stem cell biologists. From a clinical perspective, no other area of stem cell biology has been applied as successfully as has transplantation of bone marrow and cord blood for the treatment of blood diseases. In the last few years, research in stem cell biology has expanded rapidly to include the study of stem cells from embryonic, fetal, and various adult tissues, engendering novel perspectives regarding the identity, origin, and full therapeutic potential of tissue-specific item cells. Rather than focusing on the use of cord blood stem cells for reconstitution of bone marrow, this article reviews the biology of stem cells found in the cord blood in the context of cell plasticity and their therapeutic potential for repair of the nervous system.
引用
收藏
页码:358 / 369
页数:12
相关论文
共 81 条
  • [1] Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats - similarities to astrocyte grafts
    Azizi, SA
    Stokes, D
    Augelli, BJ
    DiGirolamo, C
    Prockop, DJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) : 3908 - 3913
  • [2] Bicknese AR, 2002, CELL TRANSPLANT, V11, P261
  • [3] Turning brain into blood: A hematopoietic fate adopted by adult neural stem cells in vivo
    Bjornson, CRR
    Rietze, RL
    Reynolds, BA
    Magli, MC
    Vescovi, AL
    [J]. SCIENCE, 1999, 283 (5401) : 534 - 537
  • [4] Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke
    Borlongan, CV
    Hadman, M
    Sanberg, CD
    Sanberg, PR
    [J]. STROKE, 2004, 35 (10) : 2385 - 2389
  • [5] Neuro-glial differentiation of human bone marrow stem cells in vitro
    Bossolasco, P
    Cova, L
    Calzarossa, C
    Rimoldi, SG
    Borsotti, C
    Deliliers, GL
    Silani, V
    Soligo, D
    Polli, E
    [J]. EXPERIMENTAL NEUROLOGY, 2005, 193 (02) : 312 - 325
  • [6] From marrow to brain: Expression of neuronal phenotypes in adult mice
    Brazelton, TR
    Rossi, FMV
    Keshet, GI
    Blau, HM
    [J]. SCIENCE, 2000, 290 (5497) : 1775 - 1779
  • [7] Buzanska L, 2002, J CELL SCI, V115, P2131
  • [8] Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow
    Campagnoli, C
    Roberts, IAG
    Kumar, S
    Bennett, PR
    Bellantuono, I
    Fisk, NM
    [J]. BLOOD, 2001, 98 (08) : 2396 - 2402
  • [9] Smooth muscle cells in human coronary atherosclerosis can originate from cells administered at marrow transplantation
    Caplice, NM
    Bunch, TJ
    Stalboerger, PG
    Wang, SH
    Simper, D
    Miller, DV
    Russell, SJ
    Litzow, MR
    Edwards, WD
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (08) : 4754 - 4759
  • [10] Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats
    Chen, JL
    Sanberg, PR
    Li, Y
    Wang, L
    Lu, M
    Willing, AE
    Sanchez-Ramos, J
    Chopp, M
    [J]. STROKE, 2001, 32 (11) : 2682 - 2688