Cell intrinsic TGF-β1 regulation of B cells

被引：31

作者：

Gros, Marilyn J. ^{[1
]}

Naquet, Philippe ^{[1
]}

Guinamard, Rodolphe R. ^{[1
]}

机构：

[1] Aix Marseille Univ, CNRS, INSERM, Fac Sci Luminy,Ctr Immunol Marseille Luminy,U631,, F-13288 Marseille 09, France

来源：

JOURNAL OF IMMUNOLOGY | 2008年 / 180卷 / 12期

关键词：

D O I：

10.4049/jimmunol.180.12.8153

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

TGF-beta family cytokines play multiple roles in immune responses. TGF-beta 1-null mice suffer from multi-organ infiltration that leads to their premature death. T cells play a central role in the TGF-beta 1 phenotype, as deficiency of TGF-beta I only in T cells reproduces the lethal phenotype. Although it is known that TGF-beta 1 controls B cells isotype switch and homeostasis, the source responsible for this control has not been characterized. Because of the major role that T cells play in regulating B cell responses, we addressed the T cell dependency of the TGF-beta 1 control of B cells. The analysis of T cell-deficient, TGF-beta 1 knockout mice and the production of chimeras in which B but not T cells lacked TGF-beta 1 allowed us to show that B cells are controlled in part by cell autonomous production of TGF-beta 1.

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收藏

页码：8153 / 8158

页数：6

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