Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp IFB-E015

被引：186

作者：

Jiao, Rui H. ^{[1
]}

Xu, Shu ^{[1
]}

Liu, Jun Y. ^{[1
]}

Ge, Hui M. ^{[1
]}

Ding, Hui ^{[1
]}

Xu, Chen ^{[1
]}

Zhu, Hai L. ^{[1
]}

Tan, Ren X. ^{[1
]}

机构：

[1] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Inst Funct Biomol, Nanjing 210093, Peoples R China

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 25期

关键词：

D O I：

10.1021/ol062257t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chaetominine (1), an alkaloidal metabolite with a new framework, was characterized from the solid-substrate culture of Chaetomium sp. IFB-E015, an endophytic fungus on the apparently healthy Adenophora axilliflora leaves. Its structure was determined by a combination of its spectral data and single-crystal X-ray diffraction analysis, with its absolute configuration elucidated by Marfey's method. Chaetominine was more cytotoxic than 5-fluorouracil against the human leukemia K562 and colon cancer SW1116 cell lines.

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页码：5709 / 5712

页数：4

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