Solid-phase synthesis and characterization of a novel fullerene-peptide derived from histone H3

被引：17

作者：

Bianco, A ^{[1
]}

Pantarotto, D

Hoebeke, J

Briand, JP

Prato, M

机构：

[1] CNRS, UPR 9021, Inst Mol & Cellular Biol, F-67084 Strasbourg, France

[2] Univ Trieste, Dept Pharmaceut Sci, I-34127 Trieste, Italy

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 23期

关键词：

D O I：

10.1039/b311505d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A peptide analogue from a histone H3 protein containing the L-fulleropyrrolidino-glutamic acid has been prepared by a solid-phase approach and has been fully characterized. By molecular modelling it was verified that this peptide derivative is able to retain a binding capacity to the MHC (major histocompatibility complex) molecule similar to that of the cognate epitope.

引用

页码：4141 / 4143

页数：3

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