SNAP-25 is present on chromaffin granules and acts as a SNAP receptor

被引：32

作者：

Tagaya, M

Genma, T

Yamamoto, A

Kozaki, S

Mizushima, S

机构：

[1] KANSAI MED UNIV,DEPT PHYSIOL,MORIGUCHI,OSAKA 570,JAPAN

[2] UNIV OSAKA PREFECTURE,COLL AGR,DEPT VET SCI,SAKAI,OSAKA 593,JAPAN

来源：

FEBS LETTERS | 1996年 / 394卷 / 01期

关键词：

chromaffin granule; N-ethylmaleimide-sensitive factor; soluble NSF attachment protein;

D O I：

10.1016/0014-5793(96)00932-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SNAP-25 is located on the plasma membrane and essential for exocytosis of neurotransmitters. It was suggested that SNAP-25 and syntaxin 1 via the interaction,vith VAMP-2 located on synaptic vesicles mediate the docking of the vesicles with the plasma membrane, In the present study, by means of biochemical and morphological analyses, we showed that SNAP-25 is present on chromaffin granules as well as on the plasma membrane. Reconstitution and immunoprecipitation analyses revealed that SNAP-25 on chromaffin granules has essentially the same properties as does SNAP-25 on the plasma membrane.

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收藏

页码：83 / 86

页数：4

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