From information to knowledge: new technologies for defining gene function

被引:10
作者
Collins, Sean R. [1 ]
Weissman, Jonathan S. [2 ,3 ,4 ]
Krogan, Nevan J. [2 ,3 ,4 ]
机构
[1] Stanford Univ, BioX Program, Stanford, CA 94305 USA
[2] Univ Calif San Francisco, Calif Inst Quantitat Biomed Res, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
[4] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA
关键词
HIGH-THROUGHPUT; SACCHAROMYCES-CEREVISIAE; FISSION YEAST; E; COLI; CELLS; GENOME; MICROARRAYS; DROSOPHILA; DELETION; MUTANTS;
D O I
10.1038/nmeth1009-721
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A wide range of methodology will be needed to bridge the gap between genome sequence and mechanistic understanding in biology. Recent advances in high-throughput genetic screening address this task.
引用
收藏
页码:721 / 723
页数:3
相关论文
共 23 条
  • [1] Microarrays of lentiviruses for gene function screens in immortalized and primary cells
    Bailey, SN
    Ali, SM
    Carpenter, AE
    Higgins, CO
    Sabatini, DM
    [J]. NATURE METHODS, 2006, 3 (02) : 117 - 122
  • [2] Bassik MC, 2009, NAT METHODS, V6, P443, DOI [10.1038/NMETH.1330, 10.1038/nmeth.1330]
  • [3] Branson K, 2009, NAT METHODS, V6, P451, DOI [10.1038/NMETH.1328, 10.1038/nmeth.1328]
  • [4] A comprehensive strategy enabling high-resolution functional analysis of the yeast genome
    Breslow, David K.
    Cameron, Dale M.
    Collins, Sean R.
    Schuldiner, Maya
    Stewart-Ornstein, Jacob
    Newman, Heather W.
    Braun, Sigurd
    Madhani, Hiten D.
    Krogan, Nevan J.
    Weissman, Jonathan S.
    [J]. NATURE METHODS, 2008, 5 (08) : 711 - 718
  • [5] eSGA:: E. coli synthetic genetic array analysis
    Butland, Gareth
    Babu, Mohan
    Diaz-Mejia, J. Javier
    Bohdana, Fedyshyn
    Phanse, Sadhna
    Gold, Barbara
    Yang, Wenhong
    Li, Joyce
    Gagarinova, Alla G.
    Pogoutse, Oxana
    Mori, Hirotada
    Wanner, Barry L.
    Lo, Henry
    Wasniewski, Jas
    Christopoulos, Constantine
    Ali, Mehrab
    Venn, Pascal
    Safavi-Naini, Anahita
    Sourour, Natalie
    Caron, Simone
    Choi, Ja-Yeon
    Laigle, Ludovic
    Nazarians-Armavil, Anaies
    Deshpande, Avnish
    Joe, Sarah
    Datsenko, Kirill A.
    Yamamoto, Natsuko
    Andrews, Brenda J.
    Boone, Charles
    Ding, Huiming
    Sheikh, Bilal
    Moreno-Hagelsieb, Gabriel
    Greenblatt, Jack F.
    Emili, Andrew
    [J]. NATURE METHODS, 2008, 5 (09) : 789 - 795
  • [6] Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans
    Chung, Kwanghun
    Crane, Matthew M.
    Lu, Hang
    [J]. NATURE METHODS, 2008, 5 (07) : 637 - 643
  • [7] Dankert H, 2009, NAT METHODS, V6, P297, DOI [10.1038/NMETH.1310, 10.1038/nmeth.1310]
  • [8] Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles
    Decourty, Laurence
    Saveanu, Cosmin
    Zemam, Kenza
    Hantraye, Florence
    Frachon, Emmanuel
    Rousselle, Jean-Claude
    Fromont-Racine, Micheline
    Jacquier, Alain
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (15) : 5821 - 5826
  • [9] Automated screening for mutants affecting dopaminergic-neuron specification in C-elegans
    Doitsidou, Maria
    Flames, Nuria
    Lee, Albert C.
    Boyanov, Alexander
    Hobert, Oliver
    [J]. NATURE METHODS, 2008, 5 (10) : 869 - 872
  • [10] Guignet EG, 2008, NAT METHODS, V5, P393, DOI [10.1038/nmeth.1201, 10.1038/NMETH.1201]