Putting tumours in context

被引：1622

作者：

Bissell, MJ ^{[1
]}

Radisky, D ^{[1
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA

来源：

NATURE REVIEWS CANCER | 2001年 / 1卷 / 01期

关键词：

D O I：

10.1038/35094059

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The interactions between cancer cells and their micro- and macroenvironment create a context that promotes tumour growth and protects it from immune attack. The functional association of cancer cells with their surrounding tissues forms a new 'organ' that changes as malignancy progresses. Investigation of this process might provide new insights into the mechanisms of tumorigenesis and could also lead to new therapeutic targets.

引用

页码：46 / 54

页数：9

共 150 条

[61]

Javaherian A, 1998, CANCER RES, V58, P2200

[62] Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. [J].

Joensuu, H ;

Roberts, PJ ;

Sarlomo-Rikala, M ;

Andersson, LC ;

Tervahartiala, P ;

Tuveson, D ;

Silberman, SL ;

Capdeville, R ;

Dimitrijevic, S ;

Druker, B ;

Demetri, GD .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (14) :1052-1056

[63] Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice [J].

Kaplan, DH ;

Shankaran, V ;

Dighe, AS ;

Stockert, E ;

Aguet, M ;

Old, LJ ;

Schreiber, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (13) :7556-7561

[64] Physiological regulation of the immunological synapse by agrin [J].

Khan, AA ;

Bose, C ;

Yam, LS ;

Soloski, MJ ;

Rupp, F .

SCIENCE, 2001, 292 (5522) :1681-1686

[65] Reduced levels of connexin43 in cervical dysplasia: inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression [J].

King, TJ ;

Fukushima, LH ;

Hieber, AD ;

Shimabukuro, KA ;

Sakr, WA ;

Bertram, JS .

CARCINOGENESIS, 2000, 21 (06) :1097-1109

[66] Interleukin-6 regulation of matrix metalloproteinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non-Hodgkin's lymphomas [J].

Kossakowska, AE ;

Edwards, DR ;

Prusinkiewicz, C ;

Zhang, MC ;

Guo, DL ;

Urbanski, SJ ;

Grogan, T ;

Marquez, LA ;

Janowska-Wieczorek, A .

BLOOD, 1999, 94 (06) :2080-2089

[67] Differential effect of subcellular localization of communication impairing gap junction protein connexin43 on tumor cell growth in vivo [J].

Krutovskikh, VA ;

Troyanovsky, SM ;

Piccoli, C ;

Tsuda, H ;

Asamoto, M ;

Yamasaki, H .

ONCOGENE, 2000, 19 (04) :505-513

[68] The gap junction communication channel [J].

Kumar, NM ;

Gilula, NB .

CELL, 1996, 84 (03) :381-388

[69] Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells [J].

Lagneaux, L ;

Delforge, A ;

Bron, D ;

De Bruyn, C ;

Stryckmans, P .

BLOOD, 1998, 91 (07) :2387-2396

[70] Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells [J].

Lee, SW ;

Reimer, CL ;

Oh, P ;

Campbell, DB ;

Schnitzer, JE .

ONCOGENE, 1998, 16 (11) :1391-1397

← 2 3 4 5 6 7 8 9 10 11 →