Putting tumours in context

被引:1622
作者
Bissell, MJ [1 ]
Radisky, D [1 ]
机构
[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
关键词
D O I
10.1038/35094059
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The interactions between cancer cells and their micro- and macroenvironment create a context that promotes tumour growth and protects it from immune attack. The functional association of cancer cells with their surrounding tissues forms a new 'organ' that changes as malignancy progresses. Investigation of this process might provide new insights into the mechanisms of tumorigenesis and could also lead to new therapeutic targets.
引用
收藏
页码:46 / 54
页数:9
相关论文
共 150 条
[61]  
Javaherian A, 1998, CANCER RES, V58, P2200
[62]   Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. [J].
Joensuu, H ;
Roberts, PJ ;
Sarlomo-Rikala, M ;
Andersson, LC ;
Tervahartiala, P ;
Tuveson, D ;
Silberman, SL ;
Capdeville, R ;
Dimitrijevic, S ;
Druker, B ;
Demetri, GD .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (14) :1052-1056
[63]   Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice [J].
Kaplan, DH ;
Shankaran, V ;
Dighe, AS ;
Stockert, E ;
Aguet, M ;
Old, LJ ;
Schreiber, RD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (13) :7556-7561
[64]   Physiological regulation of the immunological synapse by agrin [J].
Khan, AA ;
Bose, C ;
Yam, LS ;
Soloski, MJ ;
Rupp, F .
SCIENCE, 2001, 292 (5522) :1681-1686
[65]   Reduced levels of connexin43 in cervical dysplasia: inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression [J].
King, TJ ;
Fukushima, LH ;
Hieber, AD ;
Shimabukuro, KA ;
Sakr, WA ;
Bertram, JS .
CARCINOGENESIS, 2000, 21 (06) :1097-1109
[66]   Interleukin-6 regulation of matrix metalloproteinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non-Hodgkin's lymphomas [J].
Kossakowska, AE ;
Edwards, DR ;
Prusinkiewicz, C ;
Zhang, MC ;
Guo, DL ;
Urbanski, SJ ;
Grogan, T ;
Marquez, LA ;
Janowska-Wieczorek, A .
BLOOD, 1999, 94 (06) :2080-2089
[67]   Differential effect of subcellular localization of communication impairing gap junction protein connexin43 on tumor cell growth in vivo [J].
Krutovskikh, VA ;
Troyanovsky, SM ;
Piccoli, C ;
Tsuda, H ;
Asamoto, M ;
Yamasaki, H .
ONCOGENE, 2000, 19 (04) :505-513
[68]   The gap junction communication channel [J].
Kumar, NM ;
Gilula, NB .
CELL, 1996, 84 (03) :381-388
[69]   Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells [J].
Lagneaux, L ;
Delforge, A ;
Bron, D ;
De Bruyn, C ;
Stryckmans, P .
BLOOD, 1998, 91 (07) :2387-2396
[70]   Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells [J].
Lee, SW ;
Reimer, CL ;
Oh, P ;
Campbell, DB ;
Schnitzer, JE .
ONCOGENE, 1998, 16 (11) :1391-1397