Drugs in the environment:: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources -: a review

被引:847
作者
Kümmerer, K [1 ]
机构
[1] Univ Hosp Freiburg, Inst Environm Med & Hosp Epidemiol, D-79106 Freiburg, Germany
关键词
pharmaceutical; drug; hospital effluent; antibiotic; cytotoxic; antineoplastic; diagnostic agent; disinfectant; anaesthetic; AOX; gadolinium; platinum;
D O I
10.1016/S0045-6535(01)00144-8
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
After administration, pharmaceuticals are excreted by the patients into wastewater. Unused medications are sometimes disposed of in drains, The drugs enter the aquatic environment and eventually reach drinking water if they are not biodegraded or eliminated during sewage treatment. Additionally, antibiotics and disinfectants are supposed to disturb the wastewater treatment process and the microbial ecology in surface waters. Furthermore, resistant bacteria may be selected in the aeration tanks of STPs by the antibiotic substances present. Recently, pharmaceuticals have been detected in surface water, ground water and drinking water. However, only little is known about the significance of emissions from households and hospitals. A brief summary of input by different sources, occurrence, and elimination of different pharmaceutical groups such as antibiotics, anti-tumour drugs, anaesthetics and contrast media as well as AOX resulting from hospital effluent input into sewage water and surface water will be presented. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:957 / 969
页数:13
相关论文
共 118 条
  • [61] Hospital effluents as a source of gadolinium in the aquatic environment
    Kümmerer, K
    Helmers, E
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2000, 34 (04) : 573 - 577
  • [62] Biodegradability of antineoplastic compounds in screening tests:: influence of glucosidation and of stereochemistry
    Kümmerer, K
    Al-Ahmad, A
    Bertram, B
    Wiessler, M
    [J]. CHEMOSPHERE, 2000, 40 (07) : 767 - 773
  • [63] Analysis of benzalkonium chloride in the effluent from European hospitals by solid-phase extraction and high-performance liquid chromatography with post-column ion-pairing and fluorescence detection
    Kummerer, K
    Eitel, A
    Braun, U
    Hubner, P
    Daschner, F
    Mascart, G
    Milandri, M
    Reinthaler, F
    Verhoef, J
    [J]. JOURNAL OF CHROMATOGRAPHY A, 1997, 774 (1-2) : 281 - 286
  • [64] Biodegradability of the anti-tumour agent ifosfamide and its occurrence in hospital effluents and communal sewage
    Kummerer, K
    StegerHartmann, T
    Meyer, M
    [J]. WATER RESEARCH, 1997, 31 (11) : 2705 - 2710
  • [65] European hospitals as a source for platinum in the environment in comparison with other sources
    Kümmerer, K
    Helmers, E
    Hubner, P
    Mascart, G
    Milandri, M
    Reinthaler, F
    Zwakenberg, M
    [J]. SCIENCE OF THE TOTAL ENVIRONMENT, 1999, 225 (1-2) : 155 - 165
  • [66] Biodegradability of the anti-tumour agents 5-fluorouracil, cytarabine, and gemcitabine:: Impact of the chemical structure and synergistic toxicity with hospital effluent
    Kümmerer, K
    Al-Ahmad, A
    [J]. ACTA HYDROCHIMICA ET HYDROBIOLOGICA, 1997, 25 (04): : 166 - 172
  • [67] Biodegradability of some antibiotics, elimination of the genotoxicity and affection of wastewater bacteria in a simple test
    Kümmerer, K
    Al-Ahmad, A
    Mersch-Sundermann, V
    [J]. CHEMOSPHERE, 2000, 40 (07) : 701 - 710
  • [68] KUMMERER K, 1998, THESIS U FREIBURG
  • [69] KUMMERER K, 2001, UNPUB CANC DET PREV
  • [70] KUMMERER K, 1999, NORDW ZYT WORKSH P H, P10