Role of nutrients in the development of neonatal immune response

被引：32

作者：

Cunningham-Rundles, Susanna ^{[1
]}

Lin, Hong ^{[1
]}

Ho-Lin, Deborah ^{[1
]}

Dnistrian, Ann ^{[2
]}

Cassileth, Barrie R. ^{[3
]}

Perlman, Jeffrey M. ^{[4
]}

机构：

[1] Cornell Univ, Dept Pediat, Weill Med Coll, Div Hematol Oncol,Host Def Program, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Clin Labs, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, Integrat Med Serv, New York, NY 10021 USA

[4] Cornell Univ, Dept Pediat, Weill Med Coll, Div Neonatol, New York, NY 10021 USA

来源：

NUTRITION REVIEWS | 2009年 / 67卷 / 11期

关键词：

allergens; early life; immune system; micronutrients; pathogens; IRON-DEFICIENCY ANEMIA; PRO-INFLAMMATORY CYTOKINES; VITAMIN-A SUPPLEMENTATION; ACUTE-PHASE RESPONSE; MAITAKE BETA-GLUCAN; ZINC SUPPLEMENTATION; PRENATAL UNDERNUTRITION; HELICOBACTER-PYLORI; SELENIUM DEFICIENCY; FETAL-GROWTH;

D O I：

10.1111/j.1753-4887.2009.00236.x

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Nutrients exert unique regulatory effects in the perinatal period that mold the developing immune system. The interactions of micronutrients and microbial and environmental antigens condition the post-birth maturation of the immune system, influencing reactions to allergens, fostering tolerance towards the emerging gastrointestinal flora and ingested antigens, and defining patterns of host defense against potential pathogens. The shared molecular structures that are present on microbes or certain plants, but not expressed by human cells, are recognized by neonatal innate immune receptors. Exposure to these activators in the environment through dietary intake in early life can modify the immune response to allergens and prime the adaptive immune response towards pathogens that express the corresponding molecular structures.

引用

页码：S152 / S163

页数：12

共 124 条

[71] Plasticity of neuroendocrine-thymus interactions during ontogeny and ageing: Role of zinc and arginine [J].

Mocchegiani, Eugenio ;

Santarelli, Lory ;

Costarelli, Laura ;

Cipriano, Catia ;

Muti, Elisa ;

Giacconi, Robertina ;

Malavolta, Marco .

AGEING RESEARCH REVIEWS, 2006, 5 (03) :281-309

[72] Levels of pro-inflammatory cytokines produced from cord blood in-vitro are pathogen dependent and increased in comparison to adult controls [J].

Mohamed, Mohamed A. ;

Cunningham-Rundles, Susanne ;

Dean, Charles R. ;

Hammad, Tarek A. ;

Nesin, Mirjana .

CYTOKINE, 2007, 39 (03) :171-177

[73] Positive Association Between Helicobacter pylori and Gastroesophageal. Reflux Disease in Children [J].

Moon, Aeri ;

Solomon, Aliza ;

Beneck, Debra ;

Cunningham-Rundles, Susanna .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2009, 49 (03) :283-288

[74]

Moore Daniella Campelo Batalha Cox, 2006, Sao Paulo Med. J., V124, P298

[75] Early immunological development and mortality from infectious disease in later life [J].

Moore, Sophie E. ;

Collinson, Andrew C. ;

N'Gom, Pa Tamba ;

Aspinall, Richard ;

Prentice, Andrew M. .

PROCEEDINGS OF THE NUTRITION SOCIETY, 2006, 65 (03) :311-318

[76] Homing imprinting and immunomodulation in the gut: Role of dendritic cells and retinoids [J].

Mora, J. Rodrigo .

INFLAMMATORY BOWEL DISEASES, 2008, 14 (02) :275-289

[77] Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells [J].

Mora, J. Rodrigo ;

Iwata, Makoto ;

Eksteen, Bertus ;

Song, Si-Young ;

Junt, Tobias ;

Senman, Balimkiz ;

Otipoby, Kevin L. ;

Yokota, Aya ;

Takeuchi, Hajime ;

Ricciardi-Castagnoli, Paola ;

Rajewsky, Klaus ;

Adams, David H. ;

von Andrian, Ulrich H. .

SCIENCE, 2006, 314 (5802) :1157-1160

[78]

MOYNAHAN EJ, 1974, LANCET, V2, P399

[79] Breast milk lactoferrin regulates gene expression by binding bacterial DNA CpG motifs but not genomic DNA promoters in model intestinal cells [J].

Mulligan, P ;

White, NRJ ;

Monteleone, G ;

Wang, P ;

Wilson, JW ;

Ohtsuka, Y ;

Sanderson, IR .

PEDIATRIC RESEARCH, 2006, 59 (05) :656-661

[80] Vitamin A supplementation enhances infants' immune responses to hepatitis B vaccine but does not affect responses to Haemophilus influenzae type b vaccine [J].

Newton, Sam ;

Owusu-Agyei, Seth ;

Ampofo, William ;

Zandoh, Charles ;

Adjuik, Martin ;

Adjei, George ;

Tchum, Samuel ;

FilteaU, Suzanne ;

Kirkwood, Betty R. .

JOURNAL OF NUTRITION, 2007, 137 (05) :1272-1277

← 3 4 5 6 7 8 9 10 11 12 →