Extracellular vesicles: masters of intercellular communication and potential clinical interventions

被引：484

作者：

Pitt, Jonathan M. ^{[1
,2
,3
]}

Kroemer, Guido ^{[4
,5
,6
,7
,8
,9
,10
]}

Zitvogel, Laurence ^{[1
,2
,3
,11
,12
]}

机构：

[1] Inst Cancerol Gustave Roussy Canc Campus GRCC, Villejuif, France

[2] INSERM, U1015, Villejuif, France

[3] Univ Paris Saclay, Univ Paris 11, Fac Med, Le Kremlin Bicetre, France

[4] INSERM, U848, Villejuif, France

[5] GRCC, Metabol Platform, Villejuif, France

[6] Ctr Rech Cordeliers, INSERM, U1138, Equipe Labellisee Ligue Canc 11, Paris, France

[7] Hop Europeen Georges Pompidou, AP HP, Pole Biol, Paris, France

[8] Univ Paris 05, Sorbonne Paris Cite, Paris, France

[9] Univ Paris 06, Paris, France

[10] Karolinska Inst, Dept Womens & Childrens Hlth, Karolinska Univ Hosp, Stockholm, Sweden

[11] Inst Curie, INSERM, U932, Paris 05, France

[12] Ctr Clin Invest Biotherapies Canc CICBT 507, Villejuif, France

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2016年 / 126卷 / 04期

基金：

欧洲研究理事会;

关键词：

CELL-DERIVED EXOSOMES; MATURE DENDRITIC CELLS; CANCER EXOSOMES; TUMOR-GROWTH; T-CELLS; MICROVESICLES; BIOGENESIS; PROTEIN; INDUCE; RNA;

D O I：

10.1172/JCI87316

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Intercellular signaling via extracellular vesicles (EVs) is an underappreciated modality of cell-cell crosstalk that enables cells to convey packages of complex instructions to specific recipient cells. EVs transmit these instructions through their cargoes of multiple proteins, nucleic acids, and specialized lipids, which are derived from their cells of origin and allow for combinatorial effects upon recipient cells. This Review series brings together the recent progress in our understanding of EV signaling in physiological and pathophysiological conditions, highlighting how certain EVs, particularly exosomes, can promote or regulate infections, host immune responses, development, and various diseases notably cancer. Given the diverse nature of EVs and their abilities to profoundly modulate host cells, this series puts particular emphasis on the clinical applications of EVs as therapeutics and as diagnostic biomarkers.

引用

页码：1139 / 1143

页数：5

共 73 条

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Toxoplasma gondii antigen-pulsed-dendritic cell-derived exosomes induce a protective immune response against T gondii infection [J].