Neoorthosiphonone A;: a nitric oxide (NO) inhibitory diterpene with new carbon skeleton from Orthosiphon stamineus

被引：16

作者：

Awale, S ^{[1
]}

Tezuka, Y ^{[1
]}

Kobayashi, M ^{[1
]}

Ueda, J ^{[1
]}

Kadota, S ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Inst Nat Med, Toyama 9300194, Japan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 07期

关键词：

D O I：

10.1016/j.tetlet.2003.12.054

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

From the aerial part of Orthosiphon stamineus from Hainan island of China, a diterpene named neoorthosiphonone A (1), having a novel carbon framework. has been isolated. Neoorthosiphonone A (1) possessed a unique unprecedented structural feature of eight-membered ring C in its structure, which may be biogenetically derived from its isopimarane precursor, orthosiphonone A, through the insertion of vinyl group into the C-13-C-14 bond. Neoorthosiphonone A (1) displayed potent inhibitory activity on the nitric oxide production in LPS-activated macrophage-like J774.1 cells with an IC50 value of 7.08 muM, more potent than the positive control L-NMMA. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1359 / 1362

页数：4

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