Nitric oxide inhibitory isopimarane-type diterpenes from Orthosiphon stamineus of Indonesia

被引：42

作者：

Awale, S ^{[1
]}

Tezuka, Y ^{[1
]}

Banskota, AH ^{[1
]}

Adnyana, IK ^{[1
]}

Kadota, S ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Inst Nat Med, Sugitani, Toyama 9300194, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 02期

关键词：

D O I：

10.1021/np020455x

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A methanolic extract of Orthosiphon stamineus yielded six new highly oxygenated isopimarane-type diterpenes, orthosiphols U-Z (1-6), and 15 previously reported diterpenes. The isolated diterpenes all showed significant dose-dependent inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Orthosiphols A (7), B (8), D (9), and X (4) showed more potent inhibitory activities than a positive control, N-G-monomethyl-L-arginine (L-NMMA), and 1 displayed the strongest activity with an IC50 value of 6.4 muM.

引用

页码：255 / 258

页数：4

共 11 条

[1]

Four highly oxygenated isopimarane-type diterpenes of Orthosiphon stamineus [J].

Awale, S ;

Tezuka, Y ;

Banskota, AH ;

Kouda, K ;

Tun, KM ;

Kadota, S .

PLANTA MEDICA, 2002, 68 (03) :286-288

[2]

Norstaminane- and isopimarane-type diterpenes of Orthoshohon stamineus from Okinawa [J].

Awale, S ;

Tezuka, Y ;

Banskota, AH ;

Shimoji, S ;

Taira, K ;

Kadota, S .

TETRAHEDRON, 2002, 58 (27) :5503-5512

[3]

Five novel highly oxygenated diterpenes of Orthosiphon stamineus from myanmar [J].

Awale, S ;

Tezuka, Y ;

Banskota, AH ;

Kouda, K ;

Tun, KM ;

Kadota, S .

JOURNAL OF NATURAL PRODUCTS, 2001, 64 (05) :592-596

[4]

*BURM MED RES I, 1967, BURM IND MED PLANTS, V1, P126

[5]

The Griess assay: Suitable for a bio-guided fractionation of anti-inflammatory plant extracts? [J].

Dirsch, VM ;

Stuppner, H ;

Vollmar, AM .

PLANTA MEDICA, 1998, 64 (05) :423-426

[6]

ORTHOSIPHOL-A AND ORTHOSIPHOL-B, NOVEL DITERPENOID INHIBITORS OF TPA (12-O-TETRADECANOYLPHORBOL-13-ACETATE)-INDUCED INFLAMMATION, FROM ORTHOSIPHON-STAMINEUS [J].

MASUDA, T ;

MASUDA, K ;

SHIRAGAMI, S ;

JITOE, A ;

NAKATANI, N .

TETRAHEDRON, 1992, 48 (33) :6787-6792

[7]

*PT EIS IND, 1995, MED HERB IND IND, P263

[8]

Shibuya H, 1999, CHEM PHARM BULL, V47, P911

[9]

ORTHOSIPHOL D AND E, MINOR DITERPENES FROM ORTHOSIPHON-STAMINEUS [J].

TAKEDA, Y ;

MATSUMOTO, T ;

TERAO, H ;

SHINGU, T ;

FUTATSUISHI, Y ;

NOHARA, T ;

KAJIMOTO, T .

PHYTOCHEMISTRY, 1993, 33 (02) :411-415

[10]

Tezuka Y, 2000, CHEM PHARM BULL, V48, P1711, DOI 10.1248/cpb.48.1711

← 1 2 →