Synthesis of biologically active amines via rhodium-bisphosphite-catalyzed hydroaminomethylation

被引：60

作者：

Briggs, JR ^{[1
]}

Klosin, J ^{[1
]}

Whiteker, GT ^{[1
]}

机构：

[1] Dow Chem Co USA, Chem Sci, Midland, MI 48674 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 22期

关键词：

D O I：

10.1021/ol050848y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] We report the use of a highly regioselective rhodium-bisphosphite catalyst for olefin hydroaminomethylation. This catalyst system was successfully applied in the synthesis of two biologically active tertiary amines, ibutilide and aripiprazole.

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收藏

页码：4795 / 4798

页数：4

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