Studies on the nonmevalonate pathway:: formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate from 2-phospho-4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol

被引：91

作者：

Takagi, M

Kuzuyama, T

Kaneda, K

Watanabe, H

Dairi, T

Seto, H ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo 1130032, Japan

[2] Toyama Prefectural Univ, Biotechnol Res Ctr, Toyama 9390398, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 18期

基金：

日本学术振兴会;

关键词：

isopentenyl diphosphate; 2-phospho-4-(cytidine 5 '-diphospho)-2-C-methyl-D-erythritol; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase;

D O I：

10.1016/S0040-4039(00)00375-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol was transformed to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate by a novel Escherichia coli enzyme involved in the nonmevalonate pathway. (C) 2000 Elsevier Science Ltd. All rights reserved.

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收藏

页码：3395 / 3398

页数：4

相关论文

共 12 条

[1] Studies on the nonmevalonate pathway:: conversion of 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol to its 2-phospho derivative by 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol kinase [J].

Kuzuyama, T ;

Takagi, M ;

Kaneda, K ;

Watanabe, H ;

Dairi, T ;

Seto, H .

TETRAHEDRON LETTERS, 2000, 41 (16) :2925-2928

[2] Formation of 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol from 2-C-methyl-D-erythritol 4-phosphate by 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, a new enzyme in the nonmevalonate pathway [J].

Kuzuyama, T ;

Takagi, M ;

Kaneda, K ;

Dairi, T ;

Seto, H .

TETRAHEDRON LETTERS, 2000, 41 (05) :703-706

[3] Direct formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose 5-phosphate by 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a new enzyme in the non-mevalonate pathway to isopentenyl diphosphate [J].

Kuzuyama, T ;

Takahashi, S ;

Watanabe, H ;

Seto, H .

TETRAHEDRON LETTERS, 1998, 39 (25) :4509-4512

[4] A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway [J].

Lange, BM ;

Wildung, MR ;

McCaskill, D ;

Croteau, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) :2100-2104

[5] Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis [J].

Lois, LM ;

Campos, N ;

Putra, SR ;

Danielsen, K ;

Rohmer, M ;

Boronat, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) :2105-2110

[6] Biosynthesis of terpenoids:: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol [J].

Lüttgen, H ;

Rohdich, F ;

Herz, S ;

Wungsintaweekul, J ;

Hecht, S ;

Schuhr, CA ;

Fellermeier, M ;

Sagner, S ;

Zenk, MH ;

Bacher, A ;

Eisenreich, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (03) :1062-1067

[7] Effect of oxidative stress on the biosynthesis of 2-C-methyl-D-erythritol-2,4-cyclopyrophosphate and isoprenoids by several bacterial strains [J].

Ostrovsky, D ;

Diomina, G ;

Lysak, E ;

Matveeva, E ;

Ogrel, O ;

Trutko, S .

ARCHIVES OF MICROBIOLOGY, 1998, 171 (01) :69-72

[8] Cytidine 5′-triphosphate-dependent biosynthesis of isoprenoids:: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol [J].

Rohdich, F ;

Wungsintaweekul, J ;

Fellermeier, M ;

Sagner, S ;

Herz, S ;

Kis, K ;

Eisenreich, W ;

Bacher, A ;

Zenk, MH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (21) :11758-11763

[9]

Rohmer, 1999, COMPREHENSIVE NATURA, V2, P45

[10] Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol [J].

Sprenger, GA ;

Schorken, U ;

Wiegert, T ;

Grolle, S ;

deGraaf, AA ;

Taylor, SV ;

Begley, TP ;

BringerMeyer, S ;

Sahm, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (24) :12857-12862