A facile three-step synthesis of (±)-crispine A via an acyliminium ion cyclisation

被引：44

作者：

King, Frank D. ^{[1
]}

机构：

[1] GlaxoSmithKline, Neurol & GI CEDD, Harlow CM19 5AW, Essex, England

来源：

TETRAHEDRON | 2007年 / 63卷 / 09期

关键词：

(+/-)-crispine A; acyliminium; cyclisation;

D O I：

10.1016/j.tet.2006.12.041

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A high yielding cyclisation of the readily available N-(4,4-diethoxybutyl)-2-(3,4-dimethoxyphenyl)acetamide to 8,9-bis(methyloxy)-2,3,6, 10b-tetrahydropyrrolo[2, I-a]isoquinolin-5(1H)-one is described. The latter can be reduced with either AlH3 or BH3 to (+/-)-crispine A in an overall yield of 55%. (c) 2006 Elsevier Ltd. All fights reserved.

引用

页码：2053 / 2056

页数：4

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