A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris)

被引：61

作者：

Appendino, G

Della Porta, C

Conseil, G

Sterner, O

Mercalli, E

Dumontet, C

Di Pietro, A

机构：

[1] Dipartimento Sci Chim Alimentari Farmaceut & Farm, I-28100 Novara, Italy

[2] Inst Biol & Chim Prot, F-69367 Lyon 07, France

[3] Lund Univ, Dept Organ & Bioorgan Chem, S-22100 Lund, Sweden

[4] Fac Med Rockfeller, Lab Cytol Analyt, F-69880 Lyon, France

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 01期

关键词：

D O I：

10.1021/np0203537

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The macrocyclic lathyrane polyester Euphorbia factor L-10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L-10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.

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页码：140 / 142

页数：3

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