Synthesis of enantiopure (2R,3aS,7aS)-2-ethyloctahydroindol-6-one and its Fischer indolization

被引：16

作者：

Bonjoch, J

Catena, J

Terricabras, D

Fernandez, JC

LopezCanet, M

Valls, N

机构：

[1] Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 18期

关键词：

D O I：

10.1016/S0957-4166(97)00379-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A diastereoselective synthesis of (-)-2-ethyloctahydroindol-6-one 12 starting from O-methyl-L-tyrosine 1 is described. The process first involves the synthesis of enantiopure (-)-1-(4-methoxyphenyl)-2-butylamine 8, which, after Birch reduction, N-benzylation and acid treatment, renders the cis-fused azabicyclo 12. Studies on the Fischer indolization of 12 are also reported. (C) 1997 Elsevier Science Ltd.

引用

页码：3143 / 3151

页数：9

共 27 条

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