Metabolomics: towards understanding host-microbe interactions

被引:27
作者
Han, Jun [1 ]
Antunes, L. Caetano M. [2 ]
Finlay, B. Brett [2 ,3 ]
Borcherst, Christoph H. [1 ]
机构
[1] Univ Victoria, Genome BC Prote Ctr, Victoria, BC V8Z 7X8, Canada
[2] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada
[3] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z4, Canada
基金
加拿大健康研究院;
关键词
gut microbiota; host-microbe interaction; mass spectrometry; metabolomics; metagenomics; microbial profiling; nuclear magnetic resonance spectroscopy; GUT MICROBIOTA; SYSTEMS BIOLOGY; MASS-SPECTROMETRY; INTESTINAL MICROBIOTA; CLOSTRIDIUM-DIFFICILE; METAGENOMIC ANALYSIS; SYMBIOTIC BACTERIA; COLORECTAL-CANCER; IDENTIFICATION; HEALTH;
D O I
10.2217/FMB.09.132
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Metabolomics employs an array of analytical techniques, including high-resolution nuclear magnetic resonance spectroscopy and mass spectrometry, to simultaneously analyze hundreds to thousands of small-molecule metabolites in biological samples. In conjunction with chemoinformatics and bioinformatics tools, metabolomics enables comprehensive characterization of the metabolic phenotypes (metabotypes) of the human, and other mammalian, hosts that have co-evolved with a large number of diverse commensal microbes, especially in the intestinal tract. Correlation of the metabotypes with the microbial profiles derived from culture-independent molecular techniques is increasingly helping to decipher inherent and intimate host-microbe relationships. This integrated, systems biology approach is improving our understanding of the molecular mechanisms underlying multilevel host-microbe interactions, and promises to elucidate the etiologies of human disorders resulting from unfavorable human-microbial associations, including enteric infections.
引用
收藏
页码:153 / 161
页数:9
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