Chiral diphenylprolinol TES ether promoted conjugate addition-aldol-dehydration reactions between α,β-unsaturated aldehydes and 2-N-protected amino benzaldehydes

被引：122

作者：

Li, Hao ^{[1
]}

Wang, Jian ^{[1
]}

Xie, Hexin ^{[1
]}

Zu, Liansuo ^{[1
]}

Jiang, Wei ^{[1
]}

Duesler, Eileen N. ^{[1
]}

Wang, Wei ^{[1
]}

机构：

[1] Univ New Mexico, Dept Chem, Albuquerque, NM 87131 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 06期

关键词：

D O I：

10.1021/ol062877u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A conjugate addition-aldol-dehydration reaction of alpha,beta-unsaturated aldehydes with 2-N-protected amino benzaldehydes has been developed. The process is promoted by (S)-diphenylprolinol TES ether to afford synthetically useful 1,2-dihydroquinolines in high enantioselectivities with good yields.

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收藏

页码：965 / 968

页数：4

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