MicroRNAs: Novel regulators in the hallmarks of human cancer

被引：383

作者：

Ruan, Kai ^{[1
]}

Fang, Xiaoguang ^{[1
]}

Ouyang, Gaoliang ^{[1
]}

机构：

[1] Xiamen Univ, Sch Life Sci, Key Lab, Minist Educ Cell Biol & Tumor Cell Engn, Xiamen 361005, Peoples R China

来源：

CANCER LETTERS | 2009年 / 285卷 / 02期

关键词：

miRNAs; Cancer; Oncogene; Tumor-suppressor gene; Hallmark; CELL-PROLIFERATION PATHWAYS; TUMOR-SUPPRESSOR GENE; GROWTH-FACTOR-BETA; MIR-200; FAMILY; BREAST-CANCER; COLON-CANCER; MESENCHYMAL TRANSITION; SEQUENCE VARIATIONS; REPRESSORS ZEB1; IN-VIVO;

D O I：

10.1016/j.canlet.2009.04.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) are small non-coding RNAs of 18-25 nucleotides in length that function as negative regulators. miRNAs post-transcriptionally regulate gene expression by either inhibiting mRNA translation or inducing mRNA degradation, and participate in a wide variety of physiological and pathological cellular processes. Recent reports have revealed that the deregulation of miRNAs correlates with various human cancers and is involved in the initiation and progression of human cancers. miRNAs can act as oncogenes or tumor suppressors to inhibit the expression of cancer-related target genes and to promote or suppress tumorigenesis in various tissues. Therefore, abnormal miRNA expression can be regarded as a common feature of human cancers, and the identification of miRNAs and their respective targets may provide potential diagnostic and prognostic tumor biomarkers and new therapeutic strategies to treat cancers. In the present review, we discuss the emerging roles of miRNAs in the hallmarks of human cancers. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

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页码：116 / 126

页数：11

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