Structural genomics of microbes: an objective

被引：24

作者：

Kim, SH ^{[1
]}

机构：

[1] Univ Calif Berkeley, Calvin Lab, Berkeley, CA 94720 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2000年 / 10卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(00)00100-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A comparison of the genome sequences of more than 20 microorganisms reveals that a large fraction of the genes have unknown functions. Determining the structures of the proteins coded by these genes may provide additional key information in an effort to uncover the molecular functions of such proteins and new protein fold patterns. Using existing technology, it is possible to obtain a complete sequence complement and a near complete structural complement for a small microbial genome. Such information may provide a comprehensive view of a small organism, which, in turn, can serve as a platform for understanding more complex organisms.

引用

页码：380 / 383

页数：4

共 28 条

[1] Protein data bank archives of three-dimensional macromolecular structures [J].

Abola, EE ;

Sussman, JL ;

Prilusky, J ;

Manning, NO .

MACROMOLECULAR CRYSTALLOGRAPHY, PT B, 1997, 277 :556-571

[2] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[3] The past and future of structure databases [J].

Berman, HM .

CURRENT OPINION IN BIOTECHNOLOGY, 1999, 10 (01) :76-80

[4] A METHOD TO IDENTIFY PROTEIN SEQUENCES THAT FOLD INTO A KNOWN 3-DIMENSIONAL STRUCTURE [J].

BOWIE, JU ;

LUTHY, R ;

EISENBERG, D .

SCIENCE, 1991, 253 (5016) :164-170

[5] How many membrane proteins are there? [J].

Boyd, D ;

Schierle, C ;

Beckwith, J .

PROTEIN SCIENCE, 1998, 7 (01) :201-205

[6] Assessing sequence comparison methods with reliable structurally identified distant evolutionary relationships [J].

Brenner, SE ;

Chothia, C ;

Hubbard, TJP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (11) :6073-6078

[7] Assigning folds to the proteins encoded by the genome of Mycoplasma genitalium [J].

Fischer, D ;

Eisenberg, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (22) :11929-11934

[8] THE MINIMAL GENE COMPLEMENT OF MYCOPLASMA-GENITALIUM [J].

FRASER, CM ;

GOCAYNE, JD ;

WHITE, O ;

ADAMS, MD ;

CLAYTON, RA ;

FLEISCHMANN, RD ;

BULT, CJ ;

KERLAVAGE, AR ;

SUTTON, G ;

KELLEY, JM ;

FRITCHMAN, JL ;

WEIDMAN, JF ;

SMALL, KV ;

SANDUSKY, M ;

FUHRMANN, J ;

NGUYEN, D ;

UTTERBACK, TR ;

SAUDEK, DM ;

PHILLIPS, CA ;

MERRICK, JM ;

TOMB, JF ;

DOUGHERTY, BA ;

BOTT, KF ;

HU, PC ;

LUCIER, TS ;

PETERSON, SN ;

SMITH, HO ;

HUTCHISON, CA ;

VENTER, JC .

SCIENCE, 1995, 270 (5235) :397-403

[9] A structural census of the current population of protein sequences [J].

Gerstein, M ;

Levitt, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (22) :11911-11916

[10] Surprising similarities in structure comparison [J].

Gibrat, JF ;

Madej, T ;

Bryant, SH .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1996, 6 (03) :377-385

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