A functional role for the ventrolateral prefrontal cortex in non-spatial auditory cognition

被引：39

作者：

Cohen, Y. E. ^{[1
]}

Russ, B. E. ^{[2
]}

Davis, S. J. ^{[1
]}

Baker, A. E. ^{[3
]}

Ackelson, A. L. ^{[3
]}

Nitecki, R. ^{[3
]}

机构：

[1] Univ Penn, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

[2] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA

[3] Dartmouth Coll, Dept Psychol & Brain Sci, Hanover, NH 03755 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2009年 / 106卷 / 47期

关键词：

non-spatial processing; spatial processing; vocalization; LATERAL INTRAPARIETAL AREA; RHESUS-MONKEY; NEURAL REPRESENTATION; CORTICAL-NEURONS; MACAQUE MONKEY; BELT CORTEX; STREAMS; VOCALIZATIONS; SELECTIVITY; PRIMATES;

D O I：

10.1073/pnas.0907248106

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Spatial and non-spatial sensory information is hypothesized to be evaluated in parallel pathways. In this study, we tested the spatial and non-spatial sensitivity of auditory neurons in the ventrolateral prefrontal cortex (vPFC), a cortical area in the non-spatial pathway. Activity was tested while non-human primates reported changes in an auditory stimulus' spatial or non-spatial features. We found that vPFC neurons were reliably modulated during a non-spatial auditory task but were not modulated during a spatial auditory task. The degree of modulation during the non-spatial task correlated positively with the monkeys' behavioral performance. These results are consistent with the hypotheses that the vPFC is part of a circuit involved in non-spatial auditory processing and that the vPFC plays a functional role in non-spatial auditory cognition.

引用

页码：20045 / 20050

页数：6

共 43 条

[11] Prefrontal connections of the parabelt auditory cortex in macaque monkeys [J].

Hackett, TA ;

Stepniewska, I ;

Kaas, JH .

BRAIN RESEARCH, 1999, 817 (1-2) :45-58

[12] Functional referents and acoustic similarity: field playback experiments with rhesus monkeys [J].

Hauser, MD .

ANIMAL BEHAVIOUR, 1998, 55 :1647-1658

[13] Subdivisions of auditory cortex and processing streams in primates [J].

Kaas, JH ;

Hackett, TA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (22) :11793-11799

[14] 'What' and 'where' processing in auditory cortex [J].

Kaas, JH ;

Hackett, TA .

NATURE NEUROSCIENCE, 1999, 2 (12) :1045-1047

[15] The lateral intraparietal area as a salience map: the representation of abrupt onset, stimulus motion, and task relevance [J].

Kusunoki, M ;

Gottlieb, J ;

Goldberg, ME .

VISION RESEARCH, 2000, 40 (10-12) :1459-1468

[16]

LEE JH, 2009, FRON INTEGR IN PRESS

[17] Prefrontal activity predicts monkeys' decisions during an auditory category task [J].

Lee, Jung H. ;

Russ, Brian E. ;

Orr, Lauren E. ;

Cohen, Yale E. .

FRONTIERS IN INTEGRATIVE NEUROSCIENCE, 2009, 3

[18] Double dissociation of 'what' and 'where' processing in auditory cortex [J].

Lomber, Stephen G. ;

Malhotra, Shveta .

NATURE NEUROSCIENCE, 2008, 11 (05) :609-616

[19] Attention to both space and feature modulates neuronal responses in macaque area V4 [J].

McAdams, CJ ;

Maunsell, JHR .

JOURNAL OF NEUROPHYSIOLOGY, 2000, 83 (03) :1751-1755

[20] An integrative theory of prefrontal cortex function [J].

Miller, EK ;

Cohen, JD .

ANNUAL REVIEW OF NEUROSCIENCE, 2001, 24 :167-202

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