A functional role for the ventrolateral prefrontal cortex in non-spatial auditory cognition

被引：39

作者：

Cohen, Y. E. ^{[1
]}

Russ, B. E. ^{[2
]}

Davis, S. J. ^{[1
]}

Baker, A. E. ^{[3
]}

Ackelson, A. L. ^{[3
]}

Nitecki, R. ^{[3
]}

机构：

[1] Univ Penn, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

[2] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA

[3] Dartmouth Coll, Dept Psychol & Brain Sci, Hanover, NH 03755 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2009年 / 106卷 / 47期

关键词：

non-spatial processing; spatial processing; vocalization; LATERAL INTRAPARIETAL AREA; RHESUS-MONKEY; NEURAL REPRESENTATION; CORTICAL-NEURONS; MACAQUE MONKEY; BELT CORTEX; STREAMS; VOCALIZATIONS; SELECTIVITY; PRIMATES;

D O I：

10.1073/pnas.0907248106

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Spatial and non-spatial sensory information is hypothesized to be evaluated in parallel pathways. In this study, we tested the spatial and non-spatial sensitivity of auditory neurons in the ventrolateral prefrontal cortex (vPFC), a cortical area in the non-spatial pathway. Activity was tested while non-human primates reported changes in an auditory stimulus' spatial or non-spatial features. We found that vPFC neurons were reliably modulated during a non-spatial auditory task but were not modulated during a spatial auditory task. The degree of modulation during the non-spatial task correlated positively with the monkeys' behavioral performance. These results are consistent with the hypotheses that the vPFC is part of a circuit involved in non-spatial auditory processing and that the vPFC plays a functional role in non-spatial auditory cognition.

引用

页码：20045 / 20050

页数：6

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