Perivascular Multipotent Progenitor Cells in Human Organs

被引：160

作者：

Crisan, Mihaela ^{[1
]}

Chen, Chien-Wen ^{[1
]}

Corselli, Mirko ^{[1
]}

Andriolo, Gabriella ^{[2
]}

Lazzari, Lorenza ^{[2
]}

Peault, Bruno ^{[1
,3
]}

机构：

[1] Childrens Hosp Pittsburgh, Stem Cell Res Ctr, Pittsburgh, PA 15213 USA

[2] Fdn Osped Maggiore Policlin, Dept Regenerat Med, Milan, Italy

[3] McGowan Inst Regenerat Med, Pittsburgh, PA USA

来源：

HEMATOPOIETIC STEM CELLS VII | 2009年 / 1176卷

关键词：

pericyte; mesenchymal stem cell; MESENCHYMAL STEM-CELLS; BONE-MARROW; CELLULAR CARDIOMYOPLASTY; STROMAL CELLS; PERICYTES; TISSUE; HEART;

D O I：

10.1111/j.1749-6632.2009.04967.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

We have identified vascular pericytes in multiple human organs on expression of CD146, NG2, PDGF-R beta, and mesenchymal stem cell markers (CD44, CD73, CD90, CD105) and absence of blood, endothelial, and myogenic cell markers. Pericytes purified from all tissues were myogenic in culture and in vivo, sustained long-term culture during which they expressed markers of mesenchymal stem cells, and exhibited, at the clonal level, osteogenic, chondrogenic, and adipogenic potentials. These results suggest that human capillary and microvessel walls all over the organism harbor a reserve of progenitor cells that are at the origin of the elusive mesenchymal stem cells, so far identified only retrospectively in primary tissue cultures.

引用

页码：118 / 123

页数：6

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