Genetic mechanisms underlying male sex determination in mammals

被引：33

作者：

Piprek, R. P. ^{[1
]}

机构：

[1] Jagiellonian Univ, Dept Comparat Anat, Inst Zool, PL-30060 Krakow, Poland

来源：

JOURNAL OF APPLIED GENETICS | 2009年 / 50卷 / 04期

关键词：

Fgf9; gonadal differentiation; Sertoli cells; sex reversal; sex determination; Sry; Sox9; DETERMINING FACTOR SRY; MOBILITY GROUP DOMAIN; MULTIPLE CONGENITAL-ANOMALIES; PROSTAGLANDIN-D SYNTHASE; PRE-SERTOLI CELLS; TESTIS DEVELOPMENT; NUCLEAR-LOCALIZATION; GONADAL DEVELOPMENT; STEROIDOGENIC FACTOR-1; DETERMINING REGION;

D O I：

10.1007/BF03195693

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Genetic control of gonadal development proceeds through either the male or female molecular pathways, driving bipotential gonadal anlage differentiation into a testis or ovary. Antagonistic interactions between the 2 pathways determine the gonadal sex. Essentially sex determination is the enhancement of one of the 2 pathways according to genetic sex. Initially, Sry with other factors upregulates Sox9 expression in XY individuals. Afterwards the expression of Sox9 is maintained by a positive feedback loop with Fgf9 and prostaglandin D-2 as well as by autoregulative ability of Sox9. If these factors reach high concentrations, then Sox9 and/or Fgf9 may inhibit the female pathway. Surprisingly, splicing, nuclear transport, and extramatrix proteins may be involved ill sex determination. The male sex determination pathway switches oil the expression of Belles driving Sertoli cell differentiation. Sertoli cells orchestrate testicular differentiation. In the absence of Sry, the predomination of the female pathway results ill the realization of a robust genetic program that drives ovarian differentiation

引用

页码：347 / 360

页数：14

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