Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterus

被引：113

作者：

Kallikourdis, Marinos ^{[1
]}

Andersen, Kristian G. ^{[1
]}

Welch, Katie A. ^{[1
]}

Betz, Alexander G. ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2007年 / 104卷 / 02期

基金：

英国医学研究理事会;

关键词：

effector T cells; pregnancy; tolerance; chemokine receptor;

D O I：

10.1073/pnas.0604268104

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Regulatory T cells play an essential role in preventing fetal rejection by the maternal immune system. Here we show that, based on the expression of CCR5, regulatory T cells can be divided into a highly suppressive CCR5(+) and a far less suppressive CCR5(-) subpopulation, suggesting that the former represent the effector arm of regulatory T cells. Although regulatory T cells from CCR5-/- gene deletion mutants still suppress, they are less effective mediators of maternal-fetal tolerance. The accumulation of CCR5(+) regulatory T cells at this site appears to be enhanced by alloantigen. This finding is in stark contrast to the systemic expansion of regulatory T cells during pregnancy, which appears to be alloantigen-independent. The fact that CCR5(+) regulatory T cells preferentially accumulate in the gravid uterus and that expression of CCR5 on regulatory T cells can be induced by activation lead us to propose that CCR5 is responsible for the accumulation of those regulatory T cells that have been activated by paternal antigens.

引用

页码：594 / 599

页数：6

共 52 条

[21] Chemokines and their receptors as markers of allograft rejection and targets for immunosuppression [J].