Recent updates on onchocerciasis: Diagnosis and treatment

被引：75

作者：

Udall, Don N. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dermatol Clin Trials Unit, La Jolla, CA 92037 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2007年 / 44卷 / 01期

关键词：

D O I：

10.1086/509325

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent progress in onchocerciasis research has led to improved understanding of the immunopathology of Onchocerca volvulus, as well as improvements in diagnosis and treatment of this morbid disease. This article reviews the recent literature, highlighting breakthroughs in sensitive means of antigen testing and an unusual new approach to therapy that targets an endosymbiotic bacterium required for filarial worm fecundity.

引用

页码：53 / 60

页数：8

共 76 条

[11]

Blanke CH, 2002, LANCET, V359, P1345

[12] Diagnostics in onchocerciasis: future challenges [J].

Boatin, BA ;

Toe, L ;

Alley, ES ;

Dembele, N ;

Weiss, N ;

Dadzie, KY .

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1998, 92 :S41-S45

[13] Detection of Onchocerca volvulus infection in low prevalence areas:: a comparison of three diagnostic methods [J].

Boatin, BA ;

Toé, L ;

Alley, ES ;

Nagelkerke, NJD ;

Borsboom, G ;

Habbema, JDF .

PARASITOLOGY, 2002, 125 :545-552

[14] Pathogenesis and host responses in human onchocerciasis:: impact of Onchocerca filariae and Wolbachia endobacteria [J].

Brattig, NW .

MICROBES AND INFECTION, 2004, 6 (01) :113-128

[15] Neutrophil accumulation around Onchocerca worms and chemotaxis of neutrophils are dependent on Wolbachia endobacteria [J].

Brattig, NW ;

Büttner, DW ;

Hoerauf, A .

MICROBES AND INFECTION, 2001, 3 (06) :439-446

[16] Development of reactive onchocercal skin lesions during a placebo-controlled trial with ivermectin among persons without lesions at baseline [J].

Brieger, WR ;

Kale, OO ;

Ososanya, OO .

TROPICAL DOCTOR, 2001, 31 (02) :96-98

[17] Analysis of renal function in onchocerciasis patients before and after therapy [J].

Burchard, GD ;

Kubica, T ;

Tischendorf, FW ;

Kruppa, T ;

Brattig, NW .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1999, 60 (06) :980-986

[18] Eosinophil sequestration and activation are associated with the onset and severity of systemic adverse reactions following the treatment of onchocerciasis with ivermectin [J].

Cooper, PJ ;

Awadzi, K ;

Ottesen, EA ;

Remick, D ;

Nutman, TB .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (03) :738-742

[19] Association of transient dermal mastocytosis and elevated plasma tryptase levels with development of adverse reactions after treatment of onchocerciasis with ivermectin [J].

Cooper, PJ ;

Schwartz, LB ;

Irani, AM ;

Awadzi, K ;

Guderian, RH ;

Nutman, TB .

JOURNAL OF INFECTIOUS DISEASES, 2002, 186 (09) :1307-1313

[20] Early human infection with onchocerca volvulus is associated with an enhanced parasite-specific cellular immune response [J].

Cooper, PJ ;

Mancero, T ;

Espinel, M ;

Sandoval, C ;

Lovato, R ;

Guderian, RH ;

Nutman, TB .

JOURNAL OF INFECTIOUS DISEASES, 2001, 183 (11) :1662-1668

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