Lipid rafts: at a crossroad between cell biology and physics

被引：878

作者：

Jacobson, Ken

Mouritsen, Ole G.

Anderson, Richard G. W.

机构：

[1] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[3] Univ So Denmark, Dept Phys, MEMPHYS Ctr Biomembrane Phys, DK-5230 Odense, Denmark

[4] Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA

来源：

NATURE CELL BIOLOGY | 2007年 / 9卷 / 01期

关键词：

D O I：

10.1038/ncb0107-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Membrane lateral heterogeneity is accepted as a requirement for the function of biological membranes and the notion of lipid rafts gives specificity to this broad concept. However, the lipid raft field is now at a technical impasse because the physical tools to study biological membranes as a liquid that is ordered in space and time are still being developed. This has lead to a disconnection between the concept of lipid rafts as derived from biochemical and biophysical assays and their existence in the cell. Here, we compare the concept of lipid rafts as it has emerged from the study of synthetic membranes with the reality of lateral heterogeneity in biological membranes. Further application of existing tools and the development of new tools are needed to understand the dynamic heterogeneity of biological membranes.

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页码：7 / 14

页数：8

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