The BDNF Val66Met Polymorphism Is Associated With Rumination in Healthy Adults

被引：55

作者：

Beevers, Christopher G. ^{[1
]}

Wells, Tony T. ^{[1
]}

McGeary, John E. ^{[2
,3
]}

机构：

[1] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA

[2] Brown Univ, Providence Vet Affairs Med Ctr, Providence, RI 02912 USA

[3] Brown Univ, Ctr Alcohol & Addict Studies, Providence, RI 02912 USA

来源：

EMOTION | 2009年 / 9卷 / 04期

关键词：

genetic association; rumination; depression; BDNF; 5-HTTLPR; PROMOTER REGION POLYMORPHISM; NEUROTROPHIC FACTOR GENE; SEROTONIN TRANSPORTER; DEPRESSION; SCHIZOPHRENIA; DYSPHORIA; SLC6A4; MEMORY;

D O I：

10.1037/a0016189

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

This study examined associations between the tendency to ruminate and 2 polymorphisms: the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and 5-HTTLPR polymorphism in the serotonin transporter gene (SLC6A4). Participants were a homogeneous group of healthy, unmedicated, never depressed individuals with few current symptoms of depression (N = 71). Results indicated that met heterozygotes of the BDNF allele were significantly more likely to ruminate than individuals homozygous for the val BDNF allele. There was no association between rumination and the 5-HTTLPR polymorphism. Furthermore, the interaction between the 5-HTTLPR and BDNF polymorphisms did not predict rumination. Results suggest that variation in the BDNF gene may contribute to the tendency to ruminate. Because this association exists in healthy adults, it may represent a susceptibility factor for affective disorders.

引用

页码：579 / 584

页数：6

共 30 条

[11]

Heils A, 1996, J NEUROCHEM, V66, P2621

[12] The BDNF Va166Met polymorphism predicts rumination and depression differently in young adolescent girls and their mothers [J].

Hilt, Lori M. ;

Sander, Lisa C. ;

Nolen-Hoeksema, Susan ;

Simen, Arthur A. .

NEUROSCIENCE LETTERS, 2007, 429 (01) :12-16

[13] An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk [J].

Hu, XZ ;

Oroszi, G ;

Chun, J ;

Smith, TL ;

Goldman, D ;

Schuckit, MA .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2005, 29 (01) :8-16

[14] Attentional bias in dysphoria: The role of inhibitory processes [J].

Joormann, J .

COGNITION & EMOTION, 2004, 18 (01) :125-147

[15] Differential effects of rumination and dysphoria on the inhibition of irrelevant emotional material: Evidence from a negative priming task [J].

Joormann, Jutta .

COGNITIVE THERAPY AND RESEARCH, 2006, 30 (02) :149-160

[16] Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region [J].

Lesch, KP ;

Bengel, D ;

Heils, A ;

Sabol, SZ ;

Greenberg, BD ;

Petri, S ;

Benjamin, J ;

Muller, CR ;

Hamer, DH ;

Murphy, DL .

SCIENCE, 1996, 274 (5292) :1527-1531

[17] Human aging magnifies genetic effects on executive functioning and working memory [J].

Nagel, Irene E. ;

Chicherio, Christian ;

Li, Shu-Chen ;

von Oertzen, Timo ;

Sander, Thomas ;

Villringer, Arno ;

Heekeren, Hauke R. ;

Backman, Lars ;

Lindenberger, Ulman .

FRONTIERS IN HUMAN NEUROSCIENCE, 2008, 2

[18] The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology [J].

Nemoto, K ;

Ohnishi, T ;

Mori, T ;

Moriguchi, Y ;

Hashimoto, R ;

Asada, T ;

Kunugi, H .

NEUROSCIENCE LETTERS, 2006, 397 (1-2) :25-29

[19] Neurobiology of depression [J].

Nestler, EJ ;

Barrot, M ;

DiLeone, RJ ;

Eisch, AJ ;

Gold, SJ ;

Monteggia, LM .

NEURON, 2002, 34 (01) :13-25

[20] The role of rumination in depressive disorders and mixed anxiety/depressive symptoms [J].

Nolen-Hoeksema, S .

JOURNAL OF ABNORMAL PSYCHOLOGY, 2000, 109 (03) :504-511

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