Pathogenic role of interleukin-21 in psoriasis

被引：15

作者：

Caruso, Roberta ^{[1
]}

Costanzo, Antonio ^{[2
]}

Monteleone, Giovanni ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dept Internal Med, Gastroenterol Unit, Rome, Italy

[2] Univ Roma Tor Vergata, Dept Internal Med, Dermatol Unit, Rome, Italy

来源：

CELL CYCLE | 2009年 / 8卷 / 22期

关键词：

IL-21; psoriasis; T cells; keratinocytes; Th1; cells; Th17; DISEASE; IL-21;

D O I：

10.4161/cc.8.22.9964

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Psoriasis is a chronic inflammatory disease of the skin characterized by keratinocyte hyperplasia and dermal infiltration with inflammatory cells. Driving factors the epidermal hyperplasia in psoriasis are not fully understood, but there is evidence that t cell-derived cytokines can be involved. In this article, we focus on the recent data indicating a key role of interleukin-21, a cytokine mostly made by activated CD4+ t cells, in promoting epidermal hyperplasia and expanding pathogenic Th cell responses in psoriasis. © 2009 Landes Bioscience.

引用

页码：3629 / 3630

页数：2

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