Guanidinium-Modified Phthalocyanines as High-Affinity G-Quadruplex Fluorescent Probes and Transcriptional Regulators

被引：169

作者：

Alzeer, Jawad ^{[1
]}

Vummidi, Balayeshwanth R. ^{[1
]}

Roth, Phillipe J. C. ^{[1
]}

Luedtke, Nathan W. ^{[1
]}

机构：

[1] Univ Zurich, Inst Organ Chem, CH-8057 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 49期

基金：

瑞士国家科学基金会;

关键词：

DNA; fluorescent probes; G-quadruplexes; polymerase chain reaction; RNA; C-MYC; HOMOLOGOUS RECOMBINATION; CATIONIC PORPHYRIN; SMALL MOLECULES; CELLULAR UPTAKE; DNA STRUCTURES; TETRAPLEX DNA; DRUG DESIGN; G-QUARTETS; IN-VIVO;

D O I：

10.1002/anie.200903685

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fluorescence is ON and transcriptional control is OFF when the guanidiniummodified zinc phthalocyanine Zn-DIGP binds a G-quadruplex DNA from the c-Myc promoter. With an equilibrium dissociation constant Kd of less than 2 nM, this interaction is the strongest binding interaction between a G-quadruplex structure and a small molecule reported to date. "chemical equation presented" © 2009 Wiley-VCH Verlag GmbH & Co. KGaA,.

引用

页码：9362 / 9365

页数：4

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