Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water

被引:2176
作者
Song, SK
Sun, SW
Ramsbottom, MJ
Chang, C
Russell, J
Cross, AH
机构
[1] Washington Univ, Dept Chem, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Biomed MR Lab, St Louis, MO 63110 USA
[3] Washington Univ, Dept Radiol, St Louis, MO 63110 USA
[4] Washington Univ, Dept Neurol, St Louis, MO 63110 USA
[5] Washington Univ, Dept Pharmacol & Mol Biol, St Louis, MO 63110 USA
[6] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan
[7] Natl Yang Ming Univ, Dept Biomed Engn, Taipei, Taiwan
关键词
D O I
10.1006/nimg.2002.1267
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Myelin loss and axonal damage are both observed in white matter injuries. Each may have significant impact on the long-term disability of patients. Currently, there does not exist a noninvasive biological marker that enables differentiation between myelin and axonal injury. We describe herein the use of magnetic resonance diffusion tensor imaging (DTI) to quantify the effect of dysmyelination on water directional diffusivities in brains of shiverer mice in vivo. The principal diffusion eigenvalues of eight axonal fiber tracts that can be identified with certainty on DTI maps were measured. The water diffusivity perpendicular to axonal fiber tracts, lambda(perpendicular to), was significantly higher in shiverer mice compared with age-matched controls, reflecting the lack of myelin and the increased freedom of cross-fiber diffusion in white matter. The water diffusivity parallel to axonal fiber tracts, lambda(parallel to), was not different, which is consistent with the presence of intact axons. It is clear that dysmyelination alone does not impact lambda(parallel to). The presence of intact axons in the setting of incomplete myelination was confirmed by electron microscopy. Although further validation is still needed, our finding suggests that changes in lambda(perpendicular to) and lambda(parallel to) may potentially be used to differentiate myelin loss versus axonal injury. (C) 2002 Elsevier Science (USA).
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收藏
页码:1429 / 1436
页数:8
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