Skeletal stem cells and their contribution to skeletal fragility: senescence and rejuvenation

被引：10

作者：

Aldahmash, Abdullah ^{[1
,2
]}

机构：

[1] King Saud Univ, Coll Med, Dept Anat, Stem Cell Unit, Riyadh, Saudi Arabia

[2] Odense Univ Hosp, Dept Endocrinol & Metab, DK-5000 Odense, Denmark

来源：

BIOGERONTOLOGY | 2016年 / 17卷 / 02期

关键词：

Skeletal stem cells; Mesenchymal stem cells; Cellular senescence; Cell therapy; Osteoporosis; HUMAN BONE-MARROW; OSTEOBLAST DIFFERENTIATION; STROMAL CELLS; ADIPOCYTE DIFFERENTIATION; MESENCHYMAL CELLS; PROGENITOR CELLS; BETA-CATENIN; LIFE-SPAN; IN-VIVO; OSTEOPOROSIS;

D O I：

10.1007/s10522-015-9623-7

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Age-related osteoporotic fractures are major health care problem worldwide and are the result of impaired bone formation, decreased bone mass and bone fragility. Bone formation is accomplished by skeletal stem cells (SSC) that are recruited to bone surfaces from bone marrow microenvironment. This review discusses targeting SSC to enhance bone formation and to abolish age-related bone fragility in the context of using stem cells for treatment of age-related disorders. Recent studies are presented that have demonstrated that SSC exhibit impaired functions during aging due to intrinsic senescence-related changes as well as the presence of senescent microenvironment. Also, a number of approaches aiming at increasing bone formation through targeting SSC and that include systemic SSC transplantation, systemic SSC targeting using aptamers or antibodies, use of therapeutic screteome and tissue engineering approaches will be presented and discussed.

引用

收藏

页码：297 / 304

页数：8

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