The on-off story of protein palmitoylation

被引：251

作者：

Bijlmakers, MJ

Marsh, M

机构：

[1] Kings Coll London, Guys Hosp, Peter Gorer Dept Immunobiol, London SE1 9RT, England

[2] UCL, Dept Biochem, London WC1E 6BT, England

[3] UCL, MRC Cell Biol Unit, MRC, LMC, London WC1E 6BT, England

来源：

TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0962-8924(02)00008-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Palmitoylation is one of the most frequent post-translational modifications found on proteins. It contributes to membrane association, protein sorting and many other processes. Through its reversibility, palmitoylation also provides mechanisms to regulate the functional activities of integral and peripheral membrane proteins. Here we discuss evidence that proteins can be palmitoylated at different locations in the cell, how targeting to these locations might be directed, and aspects of the proposed functions of palmitoylation.

引用

页码：32 / 42

页数：11

共 104 条

[41] HESS DT, 1992, J NEUROSCI, V12, P4634
[42] Persistent membrane association of activated and depalmitoylated G protein α subunits
Huang, CF
Duncan, JA
Gilman, AG
Mumby, SM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (02) : 412 - 417
[43] S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes
Kabouridis, PS
Magee, AI
Ley, SC
[J]. EMBO JOURNAL, 1997, 16 (16) : 4983 - 4998
[44] KENNEDY ME, 1994, J BIOL CHEM, V269, P31915
[45] Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization
Kraft, K
Olbrich, H
Majoul, I
Mack, M
Proudfoot, A
Oppermann, M
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (37) : 34408 - 34418
[46] AMINO-TERMINAL PALMITATE OR POLYBASIC DOMAIN CAN PROVIDE REQUIRED 2ND SIGNAL TO MYRISTATE FOR MEMBRANE-BINDING OF P56(LCK)
KWONG, J
LUBLIN, DM
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 207 (02) : 868 - 876
[47] Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein
Lee, JD
Treisman, JE
[J]. CURRENT BIOLOGY, 2001, 11 (14) : 1147 - 1152
[48] Acyl-CoA binding proteins inhibit the nonenzymic S-acylation cysteinyl-containing peptide sequences by long-chain acyl-CoAs
Leventis, R
Juel, G
Knudsen, JK
Silvius, JR
[J]. BIOCHEMISTRY, 1997, 36 (18) : 5546 - 5553
[49] Src tyrosine kinases, G(alpha) subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin - Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases
Li, SW
Couet, J
Lisanti, MP
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (46) : 29182 - 29190
[50] Mass spectrometric analysis of GAP-43/neuromodulin reveals the presence of a variety of fatty acylated species
Liang, XQ
Lu, Y
Neubert, TA
Resh, MD
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (36) : 33032 - 33040

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