The on-off story of protein palmitoylation

被引：251

作者：

Bijlmakers, MJ

Marsh, M

机构：

[1] Kings Coll London, Guys Hosp, Peter Gorer Dept Immunobiol, London SE1 9RT, England

[2] UCL, Dept Biochem, London WC1E 6BT, England

[3] UCL, MRC Cell Biol Unit, MRC, LMC, London WC1E 6BT, England

来源：

TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0962-8924(02)00008-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Palmitoylation is one of the most frequent post-translational modifications found on proteins. It contributes to membrane association, protein sorting and many other processes. Through its reversibility, palmitoylation also provides mechanisms to regulate the functional activities of integral and peripheral membrane proteins. Here we discuss evidence that proteins can be palmitoylated at different locations in the cell, how targeting to these locations might be directed, and aspects of the proposed functions of palmitoylation.

引用

页码：32 / 42

页数：11

共 104 条

[71] PROTEIN MODIFICATION - PALMITOYLATION IN G-PROTEIN SIGNALING PATHWAYS
ROSS, EM
[J]. CURRENT BIOLOGY, 1995, 5 (02) : 107 - 109
[72] The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase
Roth, AF
Feng, Y
Chen, LY
Davis, NG
[J]. JOURNAL OF CELL BIOLOGY, 2002, 159 (01) : 23 - 28
[73] Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity
Rousso, I
Mixon, MB
Chen, BK
Kim, PS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (25) : 13523 - 13525
[74] Effects of site-directed mutations of transmembrane cysteines in Sindbis virus E1 and E2 glycoproteins on palmitylation and virus replication
Ryan, C
Ivanova, L
Schlesinger, MJ
[J]. VIROLOGY, 1998, 249 (01) : 62 - 67
[75] Fatty acids on the A/USSR/77 influenza virus hemagglutinin facilitate the transition from hemifusion to fusion pore formation
Sakai, T
Ohuchi, R
Ohuchi, M
[J]. JOURNAL OF VIROLOGY, 2002, 76 (09) : 4603 - 4611
[76] Influenza viruses select ordered lipid domains during budding from the plasma membrane
Scheiffele, P
Rietveld, A
Wilk, T
Simons, K
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (04) : 2038 - 2044
[77] Endoplasmic reticulum membrane localization of Rcelp and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage
Schmidt, WK
Tam, A
Fujimura-Kamada, K
Michaelis, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (19) : 11175 - 11180
[78] Cysteine(34) of the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor is reversibly palmitoylated and required for normal trafficking and lysosomal enzyme sorting
Schweizer, A
Kornfeld, S
Rohrer, J
[J]. JOURNAL OF CELL BIOLOGY, 1996, 132 (04) : 577 - 584
[79] DETERMINATION OF THE STRUCTURAL REQUIREMENTS FOR PALMITOYLATION OF P63
SCHWEIZER, A
ROHRER, J
KORNFELD, S
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (16) : 9638 - 9644
[80] Membrane organization in immunoglobulin E receptor signaling
Sheets, ED
Holowka, D
Baird, B
[J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 1999, 3 (01) : 95 - 99

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