Gene expression cascades in pancreatic development

被引:277
作者
Wilson, ME [1 ]
Scheel, D [1 ]
German, MS [1 ]
机构
[1] Univ Calif San Francisco, Hormone Res Inst, Ctr Diabet, Dept Med, San Francisco, CA 94143 USA
关键词
pancreas; organogenesis; gene expression cascades;
D O I
10.1016/S0925-4773(02)00333-7
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The specialized endocrine and exocrine cells of the pancreas originally derive from a pool of apparently identical cells in the early gut endoderm. Serial changes in their gene expression program, controlled by a hierarchy of pancreatic transcription factors, direct this progression from multipotent progenitor cell to mature pancreatic cell. When the cells differentiate, this hierarchy of factors coalesces into a network of factors that maintain the differentiated phenotype of the cells. As we develop an understanding of the pancreatic transcription factors, we are also acquiring the tools with which we can ultimately control pancreatic cell differentiation. (C) 2002 Published by Elsevier Science Ireland Ltd.
引用
收藏
页码:65 / 80
页数:16
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