Efficient synthesis of β-amino bromides

被引：43

作者：

Nagle, AS

Salvatore, RN

Chong, BD

Jung, KW

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

[2] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Drug Discovery Program, Tampa, FL 33612 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 17期

关键词：

thionyl bromide; DMF; beta-amino bromide; bromination; aziridinium salt;

D O I：

10.1016/S0040-4039(00)00330-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

beta-Aminoalcohols were smoothly converted to beta-amino bromides using thionyl bromide and DME which were easily isolated without any further purification. Participation by the beta-amino group in brominations not only enhanced reaction rates but also promoted stereo- and regioselectivities. (C) 2000 Elsevier Science Ltd. All rights reserved.

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收藏

页码：3011 / 3014

页数：4

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