Production of recombinant proteins by methylotrophic yeasts

被引：178

作者：

Hollenberg, CP ^{[1
]}

Gellissen, G ^{[1
]}

机构：

[1] RHEIN BIOTECH GMBH, D-40595 DUSSELDORF, GERMANY

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1997年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0958-1669(97)80028-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The methylotrophic yeasts Hansenula polymorpha, Pichia pastoris and Candida boidinii have been developed as production systems for recombinant proteins. The favourable and most advantageous characteristics of these species have resulted in an increasing number of biotechnological applications. As a consequence, these species - especially H. polymorpha and P. pastoris - are rapidly becoming the systems of choice for heterologous gene expression in yeast, Recent advances in the development of these yeasts as hosts for the production of heterologous proteins have provided a catalogue of new applications, methods and system components.

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页码：554 / 560

页数：7

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