Hepatitis C virus coinfection and superinfection

被引：50

作者：

Blackard, Jason T. ^{[1
]}

Sherman, Kenneth E. ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Div Digest Dis, Cincinnati, OH 45267 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2007年 / 195卷 / 04期

关键词：

D O I：

10.1086/510858

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A hallmark of RNA viruses is their extreme genetic diversity. Within an individual, the hepatitis C virus (HCV) exists as a population of distinct but closely related viral variants, termed the "viral quasispecies." These variants may display divergent replicative capacity, cell tropism, immunologic escape, and antiviral-drug resistance. Coinfection with 2 or more distinct HCVs has been frequently documented. Moreover, several cases of HCV superinfection have been reported recently. However, few data are available regarding the clinical consequences of coinfection and superinfection, although these phenomena have important implications for HCV vaccine design and development, as well as for the efficacy of HCV therapeutic agents.

引用

页码：519 / 524

页数：6

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