Novel Biochemical Markers of Psychosocial Stress in Women

被引：67

作者：

Asberg, Marie ^{[1
]}

Nygren, Ake ^{[1
]}

Leopardi, Rosario ^{[2
]}

Rylander, Gunnar ^{[2
]}

Peterson, Ulla ^{[1
]}

Wilczek, Lukas ^{[1
]}

Kallmen, Hakan ^{[1
]}

Ekstedt, Mirjam ^{[3
,4
]}

Akerstedt, Torbjorn ^{[3
,4
]}

Lekander, Mats ^{[2
]}

Ekman, Rolf ^{[5
]}

机构：

[1] Karolinska Inst, Dept Clin Sci, Stockholm, Sweden

[2] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[3] Karolinska Inst, Inst Psychosocial Med, Stockholm, Sweden

[4] Karolinska Inst, Dept Publ Hlth, Stockholm, Sweden

[5] Gothenburg Univ, Inst Clin Neurosci, Gothenburg, Sweden

来源：

PLOS ONE | 2009年 / 4卷 / 01期

关键词：

EPIDERMAL-GROWTH-FACTOR; NF-KAPPA-B; SLEEP; CYTOKINES; PATHWAYS; CORTISOL; RHYTHMS; HEALTH; TISSUE; WORK;

D O I：

10.1371/journal.pone.0003590

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Prolonged psychosocial stress is a condition assessed through self-reports. Here we aimed to identify biochemical markers for screening and early intervention in women. Methods: Plasma concentrations of interleukin (IL) 1-alpha, IL1-beta, IL-2, IL-4, IL-6, IL-8, IL-10, interferon-gamma (INF-gamma), tumor necrosis factor-alpha (TNF-alpha), monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), thyroid stimulating hormone (TSH), total tri-iodothyronine (TT3), total thyroxine (TT4), prolactin, and testosterone were measured in: 195 women on long-term sick-leave for a stress-related affective disorder, 45 women at risk for professional burnout, and 84 healthy women. Results: We found significantly increased levels of MCP-1, VEGF and EGF in women exposed to prolonged psychosocial stress. Statistical analysis indicates that they independently associate with a significant risk for being classified as ill. Conclusions: MCP-1, EGF, and VEGF are potential markers for screening and early intervention in women under prolonged psychosocial stress.

引用

页数：5

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