Expansion of the Gene Ontology knowledgebase and resources

被引：1325

作者：

Carbon, S. ^{[1
,5
]}

Dietze, H. ^{[1
]}

Lewis, S. E. ^{[1
]}

Mungall, C. J. ^{[1
]}

Munoz-Torres, M. C. ^{[1
]}

Basu, S. ^{[2
]}

Chisholm, R. L. ^{[2
]}

Dodson, R. J. ^{[2
]}

Fey, P. ^{[2
]}

Thomas, P. D. ^{[3
,5
]}

Mi, H. ^{[3
,5
]}

Muruganujan, A. ^{[3
,5
]}

Huang, X. ^{[3
,5
]}

Poudel, S. ^{[3
,5
]}

Hu, J. C. ^{[4
,5
]}

Aleksander, S. A. ^{[4
,5
]}

McIntosh, B. K. ^{[4
,5
]}

Renfro, D. P. ^{[4
,5
]}

Siegele, D. A. ^{[4
,5
]}

Antonazzo, G. ^{[6
]}

Attrill, H. ^{[6
]}

Brown, N. H. ^{[6
]}

Marygold, S. J. ^{[6
]}

McQuilton, P. ^{[6
]}

Ponting, L. ^{[6
]}

Millburn, G. H. ^{[6
]}

Rey, A. J. ^{[6
]}

Stefancsik, R. ^{[6
]}

Tweedie, S. ^{[6
]}

Falls, K. ^{[7
]}

Schroeder, A. J. ^{[7
]}

Courtot, M. ^{[8
]}

Osumi-Sutherland, D. ^{[8
]}

Parkinson, H. ^{[8
]}

Roncaglia, P. ^{[8
]}

Lovering, R. C. ^{[9
]}

Foulger, R. E. ^{[9
]}

Huntley, R. P. ^{[9
]}

Denny, P. ^{[9
]}

Campbell, N. H. ^{[9
]}

Kramarz, B. ^{[9
]}

Patel, S. ^{[9
]}

Buxton, J. L. ^{[9
]}

Umrao, Z. ^{[9
]}

Deng, A. T. ^{[9
]}

Alrohaif, H. ^{[9
]}

Mitchell, K. ^{[9
]}

Ratnaraj, F. ^{[9
]}

Omer, W. ^{[9
]}

Rodriguez-Lopez, M. ^{[9
]}

机构：

[1] Lawrence Berkeley Natl Lab, Environm Genom & Syst Biol Div, Berkeley BioinformaticsOpen Source Projects BBOP, Berkeley, CA USA

[2] Northwestern Univ, dictyBase, Chicago, IL 60611 USA

[3] Univ Southern Calif, Dept Prevent Med, Div Bioinformat, Los Angeles, CA 90089 USA

[4] Texas A&M Univ, Dept Biol, EcoliWiki, College Stn, TX 77843 USA

[5] Texas A&M Univ, Dept Biochem & Biophys, EcoliWiki, College Stn, TX 77843 USA

[6] Univ Cambridge, Dept Physiol Dev & Neurosci, FlyBase, Cambridge, England

[7] Harvard Univ, Biol Labs, FlyBase, Cambridge, MA 02138 USA

[8] GO EMBL EBI, Hinxton, England

[9] UCL, Ctr Cardiovasc Genet, London, England

[10] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA

[11] EMBL EBI, IntAct Complex Portal, Hinxton, England

[12] EMBL EBI, InterPro, Hinxton, England

[13] Jackson Lab, MGI, 600 Main St, Bar Harbor, ME 04609 USA

[14] Univ Cambridge, PomBase, Cambridge, England

[15] UCL, PomBase, London, England

[16] Med Coll Wisconsin, RGD, Milwaukee, WI 53226 USA

[17] NYU Sch Med, Dept Biochem & Mol Pharmacol, Reactome, New York, NY USA

[18] RTI Int, Res Triangle Pk, NC USA

[19] Stanford Univ, Dept Genet, SGD, Stanford, CA 94305 USA

[20] SIB Swiss Inst Bioinformat, Geneva, Switzerland

[21] Phoenix Bioinformat, TAIR, Redwood City, CA USA

[22] UniProt EMBL EBI, Hinxton, England

[23] SIB Swiss Inst Bioinformat SIB, Geneva, Switzerland

[24] Prot Informat Resource, Washington, DC USA

[25] Prot Informat Resource, Newark, DE USA

[26] CALTECH, WormBase, Pasadena, CA 91125 USA

[27] Wellcome Trust Sanger Inst, Hinxton, England

[28] Ontario Inst Canc Res, Toronto, ON, Canada

[29] Univ Oregon, ZFIN, Eugene, OR 97403 USA

来源：

NUCLEIC ACIDS RESEARCH | 2017年 / 45卷 / D1期

基金：

美国国家卫生研究院;

关键词：

ANNOTATIONS; DATABASE; COMPLEX; QUEST;

D O I：

10.1093/nar/gkw1108

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The Gene Ontology (GO) is a comprehensive resource of computable knowledge regarding the functions of genes and gene products. As such, it is extensively used by the biomedical research community for the analysis of -omics and related data. Our continued focus is on improving the quality and utility of the GO resources, and we welcome and encourage input from researchers in all areas of biology. In this update, we summarize the current contents of the GO knowledgebase, and present several new features and improvements that have been made to the ontology, the annotations and the tools. Among the highlights are 1) developments that facilitate access to, and application of, the GO knowledgebase, and 2) extensions to the resource as well as increasing support for descriptions of causal models of biological systems and network biology. To learn more, visit http://geneontology.org/.

引用

页码：D331 / D338

页数：8

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