Antidiabetic activity of Diospyros peregrina fruit: Effect on hyperglycemia, hyperlipidemia and augmented oxidative stress in experimental type 2 diabetes

被引：106

作者：

Dewanjee, Saikat ^{[1
]}

Das, Anup K. ^{[1
]}

Sahu, Ranabir ^{[1
]}

Gangopadhyay, Moumita ^{[2
]}

机构：

[1] Jadavpur Univ, Dept Pharmaceut Technol, Adv Pharmacognosy Res Lab, Kolkata 700032, India

[2] Bose Inst, Dept Bot, Med & Plant Lab, Kolkata, India

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2009年 / 47卷 / 10期

关键词：

Diospyros peregrina; Antidiabetic; Antioxidant activity; Streptozotocin-nicotinamide; Type; 2; diabetes; ALCOHOLIC STEM EXTRACT; LIPID-PEROXIDATION; COSCINIUM-FENESTRATUM; RATS; STREPTOZOTOCIN; ANTIOXIDANTS; NICOTINAMIDE; MELLITUS; NIDDM; CELLS;

D O I：

10.1016/j.fct.2009.07.038

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Diospyros peregrina is an edible fruit of costal West-Bengal. The present investigation was undertaken to evaluate the role of aqueous extract of D. peregrina fruit in streptozotocin-nicotinamide induced type 2 diabetic rats. Oral administration of extract at the doses of 50 and 100 mg/kg body weight per day for 28 days to diabetic rats was found to possess significant dose dependant hypoglycemic and hypolipidemic activity. An increased reactive oxygen species and insufficient antioxidant activity is associated with diabetes mellitus, which is mainly responsible for diabetic pathogenesis. The role of extract on antioxidant markers of liver and kidney were estimated. The diabetic rats exhibited lower activities of superoxide dismutase (SOD), catalase (CAT). and reduced glutathione (GSH) content in hepatic and renal tissues as compared with normal rats. The activities of SOD, CAT, and GSH were found to be increased in extract treated diabetic rats in selected tissues. The increased level of lipid peroxidation (thiobarbituric acid reactive substances and hydroperoxide) in diabetic rats was also found to be reverted back to near normal status in extract treated groups. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2679 / 2685

页数：7

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