Signal transduction from multiple Ras effectors

被引：273

作者：

Katz, ME ^{[1
]}

McCormick, F ^{[1
]}

机构：

[1] ONYX PHARMACEUT, RICHMOND, CA 94806 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(97)80112-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ras proteins activate a signaling cascade through direct binding of the serine/threonine kinase Raf. They also activate additional signaling pathways that are essential for full biological activity. Candidate effecters for these pathways include RalGDS and phosphatidyl inositol 3' kinase, as well as several other Ras binding proteins the biochemical and biological properties of which are poorly understood.

引用

收藏

页码：75 / 79

页数：5

相关论文

共 50 条

[41] THE C-ELEGANS KSR-1 GENE ENCODES A NOVEL RAF-RELATED KINASE INVOLVED IN RAS-MEDIATED SIGNAL-TRANSDUCTION [J].

SUNDARAM, M ;

HAN, M .

CELL, 1995, 83 (06) :889-901

[42] Rho family GTPases: The cytoskeleton and beyond [J].

Symons, M .

TRENDS IN BIOCHEMICAL SCIENCES, 1996, 21 (05) :178-181

[43] KSR, A NOVEL PROTEIN-KINASE REQUIRED FOR RAS SIGNAL-TRANSDUCTION [J].

THERRIEN, M ;

CHANG, HC ;

SOLOMON, NM ;

KARIM, FD ;

WASSERMAN, DA ;

RUBIN, GM .

CELL, 1995, 83 (06) :879-888

[44] MITOGEN-ACTIVATED PROTEIN-KINASES MEDIATE CHANGES IN GENE-EXPRESSION, BUT NOT CYTOSKELETAL ORGANIZATION ASSOCIATED WITH CARDIAC-MUSCLE CELL HYPERTROPHY [J].

THORBURN, J ;

FROST, JA ;

THORBURN, A .

JOURNAL OF CELL BIOLOGY, 1994, 126 (06) :1565-1572

[45] Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation [J].

Urano, T ;

Emkey, R ;

Feig, LA .

EMBO JOURNAL, 1996, 15 (04) :810-816

[46] A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation [J].

White, MA ;

Vale, T ;

Camonis, JH ;

Schaefer, E ;

Wigler, MH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (28) :16439-16442

[47] MULTIPLE RAS FUNCTIONS CAN CONTRIBUTE TO MAMMALIAN-CELL TRANSFORMATION [J].

WHITE, MA ;

NICOLETTE, C ;

MINDEN, A ;

POLVERINO, A ;

VANAELST, L ;

KARIN, M ;

WIGLER, MH .

CELL, 1995, 80 (04) :533-541

[48]

Wolthuis RMF, 1996, ONCOGENE, V13, P353

[49]

Wooten MW, 1996, J NEUROCHEM, V67, P1023

[50] PURIFICATION OF A RAS-DEPENDENT MITOGEN-ACTIVATED PROTEIN-KINASE KINASE KINASE FROM BOVINE BRAIN CYTOSOL AND ITS IDENTIFICATION AS A COMPLEX OF B-RAF AND 14-13-3-PROTEINS [J].

YAMAMORI, B ;

KURODA, S ;

SHIMIZU, K ;

FUKUI, K ;

OHTSUKA, T ;

TAKAI, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (20) :11723-11726

← 1 2 3 4 5 →