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MYST family histone acetyltransferases take center stage in stem cells and development

被引：96
作者：
Voss, Anne K. [1 ,2 ]
Thomas, Tim [1 ,2 ]
机构：
[1] Walter & Eliza Hall Inst Med Res, IG Royal Parade, Parkville, Vic 3050, Australia
[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3052, Australia
来源：
BIOESSAYS | 2009年 / 31卷 / 10期
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
Hbo1; Mof; Moz; Qkf/Morf; Tip60; ACUTE MYELOID-LEUKEMIA; ORIGIN RECOGNITION COMPLEX; ZINC-FINGER PROTEIN; MONOCYTIC LEUKEMIA; DOSAGE COMPENSATION; DNA-REPLICATION; X-CHROMOSOME; SACCHAROMYCES-CEREVISIAE; SEGMENTAL IDENTITY; CYCLE PROGRESSION;
D O I：
10.1002/bies.200900051
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Acetylation of histones is an essential element regulating chromatin structure and transcription. MYST (Moz, Ybf2/Sas3, Sas2, Tip60) proteins form the largest family of histone acetyltransferases and are present in all eukaryotes. Surprisingly, until recently this protein family was poorly studied. However, in the last few years there has been a substantial increase in interest in the MYST proteins and a number of key studies have shown that these chromatin modifiers are required for a diverse range of cellular processes, both in health and disease. Translocations affecting MYST histone acetyltransferases can lead to leukemia and solid tumors. Some members of the MYST family are required for the development and self-renewal of stem cell populations; other members are essential for the prevention of inappropriate heterochromatin spreading and for the maintenance of adequate levels of gene expression. In this review we discuss the function of MYST proteins in vivo.
引用
收藏
页码：1050 / 1061
页数：12
相关论文
共 97 条
[71]   Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases [J].
Reifsnyder, C ;
Lowell, J ;
Clarke, A ;
Pillus, L .
NATURE GENETICS, 1996, 14 (01) :42-49
[72]   Purification of a pluripotent neural stem cell from the adult mouse brain [J].
Rietze, RL ;
Valcanis, H ;
Brooker, GF ;
Thomas, T ;
Voss, AK ;
Bartlett, PF .
NATURE, 2001, 412 (6848) :736-739
[73]   enok encodes a Drosophila putative histone acetyltransferase required for mushroom body neuroblast proliferation [J].
Scott, EK ;
Lee, T ;
Luo, LQ .
CURRENT BIOLOGY, 2001, 11 (02) :99-104
[74]   Androgen receptor interacts with a novel MYST protein, HBO1 [J].
Sharma, M ;
Zarnegar, M ;
Li, XY ;
Lim, B ;
Sun, ZJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (45) :35200-35208
[75]   MYST family histone acetyltransferases in the protozoan parasite Toxoplasma gondii [J].
Smith, AT ;
Tucker-Samaras, SD ;
Fairlamb, AH ;
Sullivan, WJ .
EUKARYOTIC CELL, 2005, 4 (12) :2057-2065
[76]   A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16 [J].
Smith, ER ;
Cayrou, C ;
Huang, R ;
Lane, WS ;
Côté, J ;
Lucchesi, JC .
MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (21) :9175-9188
[77]   ESA1 is a histone acetyltransferase that is essential for growth in yeast [J].
Smith, ER ;
Eisen, A ;
Gu, WG ;
Sattah, M ;
Pannuti, A ;
Zhou, JX ;
Cook, RG ;
Lucchesi, JC ;
Allis, CD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) :3561-3565
[78]   The language of covalent histone modifications [J].
Strahl, BD ;
Allis, CD .
NATURE, 2000, 403 (6765) :41-45
[79]   Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatin [J].
Suka, N ;
Luo, KH ;
Grunstein, M .
NATURE GENETICS, 2002, 32 (03) :378-383
[80]   A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM [J].
Sun, YL ;
Jiang, XF ;
Chen, SJ ;
Fernandes, N ;
Price, BD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (37) :13182-13187
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