Functionalised pyrrolidinones by conjugate addition of stabilised enolates and reformatsky reagents

被引：15

作者：

Dyer, J

Keeling, S

Moloney, MG

机构：

[1] UNIV OXFORD,DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

[2] GLAXO WELLCOME,MED RES CTR,STEVENAGE SG1 2NY,HERTS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 26期

关键词：

D O I：

10.1016/0040-4039(96)00849-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The alpha,beta-unsaturated lactam 1b has been found to readily undergo conjugate addition reactions with a range of stabilised carbon nucleophiles and Reformatsky reagents under mild conditions in good yield with high diastereoselectivity. This method provides a simple and versatile approach to highly functionalised pyrrolidinones. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：4573 / 4576

页数：4

共 32 条

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