The depletion attraction: an underappreciated force driving cellular organization

被引：308

作者：

Marenduzzo, Davide

Finan, Kieran

Cook, Peter R. ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Phys, Edinburgh EH9 3JZ, Midlothian, Scotland

[2] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

JOURNAL OF CELL BIOLOGY | 2006年 / 175卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1083/jcb.200609066

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cellular structures are shaped by hydrogen and ionic bonds, plus van der Waals and hydrophobic forces. In cells crowded with macromolecules, a little-known and distinct force - the "depletion attraction" - also acts. We review evidence that this force assists in the assembly of a wide range of cellular structures, ranging from the cytoskeleton to chromatin loops and whole chromosomes.

引用

页码：681 / 686

页数：6

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[11] Molecular crowding enhances native state stability and refolding rates of globular proteins [J].